Helix Bundle Loops Determine Whether Histidine Kinases Autophosphorylate in cis or in trans

Bacteria frequently use two-component signal transduction pathways to sense and respond to environmental and intracellular stimuli. Upon receipt of a stimulus, a homodimeric sensor histidine kinase autophosphorylates and then transfers its phosphoryl group to a cognate response regulator. The autoph...

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Bibliographic Details
Main Authors: Ashenberg, Orr, Keating, Amy E., Laub, Michael T
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101269
https://orcid.org/0000-0002-8288-7607
https://orcid.org/0000-0003-4074-8980