Gene Copy-Number Alterations: A Cost-Benefit Analysis
Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/101276 https://orcid.org/0000-0001-9837-0314 |
| _version_ | 1826212407660249088 |
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| author | Tang, Yun-Chi Amon, Angelika B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Tang, Yun-Chi Amon, Angelika B |
| author_sort | Tang, Yun-Chi |
| collection | MIT |
| description | Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy number are largely detrimental. Amplifications or deletions of specific genes can elicit discrete defects. Large-scale changes in DNA copy number can also cause detrimental phenotypes that are due to the cumulative effects of copy-number alterations of many genes simultaneously. On the other hand, studies in microorganisms show that DNA copy-number alterations can be beneficial, increasing survival under selective pressure. As DNA copy-number alterations underlie many human diseases, we will end with a discussion of gene copy-number changes as therapeutic targets. |
| first_indexed | 2024-09-23T15:21:12Z |
| format | Article |
| id | mit-1721.1/101276 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:21:12Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1012762022-09-29T14:26:54Z Gene Copy-Number Alterations: A Cost-Benefit Analysis Tang, Yun-Chi Amon, Angelika B Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Tang, Yun-Chi Amon, Angelika B. Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy number are largely detrimental. Amplifications or deletions of specific genes can elicit discrete defects. Large-scale changes in DNA copy number can also cause detrimental phenotypes that are due to the cumulative effects of copy-number alterations of many genes simultaneously. On the other hand, studies in microorganisms show that DNA copy-number alterations can be beneficial, increasing survival under selective pressure. As DNA copy-number alterations underlie many human diseases, we will end with a discussion of gene copy-number changes as therapeutic targets. National Institutes of Health (U.S.) (Grant GM56800) Human Frontier Science Program (Strasbourg, France) (Fellowship) 2016-02-25T15:58:04Z 2016-02-25T15:58:04Z 2013-01 Article http://purl.org/eprint/type/JournalArticle 00928674 1097-4172 http://hdl.handle.net/1721.1/101276 Tang, Yun-Chi, and Angelika Amon. “Gene Copy-Number Alterations: A Cost-Benefit Analysis.” Cell 152, no. 3 (January 2013): 394–405. https://orcid.org/0000-0001-9837-0314 en_US http://dx.doi.org/10.1016/j.cell.2012.11.043 Cell Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Tang, Yun-Chi Amon, Angelika B Gene Copy-Number Alterations: A Cost-Benefit Analysis |
| title | Gene Copy-Number Alterations: A Cost-Benefit Analysis |
| title_full | Gene Copy-Number Alterations: A Cost-Benefit Analysis |
| title_fullStr | Gene Copy-Number Alterations: A Cost-Benefit Analysis |
| title_full_unstemmed | Gene Copy-Number Alterations: A Cost-Benefit Analysis |
| title_short | Gene Copy-Number Alterations: A Cost-Benefit Analysis |
| title_sort | gene copy number alterations a cost benefit analysis |
| url | http://hdl.handle.net/1721.1/101276 https://orcid.org/0000-0001-9837-0314 |
| work_keys_str_mv | AT tangyunchi genecopynumberalterationsacostbenefitanalysis AT amonangelikab genecopynumberalterationsacostbenefitanalysis |