Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetr...

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Bibliographic Details
Main Authors: Fedeles, Bogdan I., Freudenthal, Bret D., Yau, Emily, Singh, Vipender, Chang, Shiou-chi, Li, Deyu, Delaney, James C., Wilson, Samuel H., Essigmann, John M.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2016
Online Access:http://hdl.handle.net/1721.1/101404
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-8241-4834
https://orcid.org/0000-0002-2196-5691
https://orcid.org/0000-0002-2494-7763

Internet

http://hdl.handle.net/1721.1/101404
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-8241-4834
https://orcid.org/0000-0002-2196-5691
https://orcid.org/0000-0002-2494-7763

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