Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse
Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping brain activation in the mouse in order to probe how sex-specific social behaviors are represented in the male brain. Our method uses the immediate-early-gen...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/101431 |
| _version_ | 1811095874088992768 |
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| author | Kim, Yongsoo Venkataraju, Kannan Umadevi Pradhan, Kith Mende, Carolin Taranda, Julian Turaga, Srinivas C. Arganda-Carreras, Ignacio Ng, Lydia Hawrylycz, Michael J. Rockland, Kathleen S. Seung, H. Sebastian Osten, Pavel Turaga, Srinivas C. Seung, H. Sebastian |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kim, Yongsoo Venkataraju, Kannan Umadevi Pradhan, Kith Mende, Carolin Taranda, Julian Turaga, Srinivas C. Arganda-Carreras, Ignacio Ng, Lydia Hawrylycz, Michael J. Rockland, Kathleen S. Seung, H. Sebastian Osten, Pavel Turaga, Srinivas C. Seung, H. Sebastian |
| author_sort | Kim, Yongsoo |
| collection | MIT |
| description | Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping brain activation in the mouse in order to probe how sex-specific social behaviors are represented in the male brain. Our method uses the immediate-early-gene c-fos, a marker of neuronal activation, visualized by serial two-photon tomography: the c-fos-GFP+ neurons are computationally detected, their distribution is registered to a reference brain and a brain atlas, and their numbers are analyzed by statistical tests. Our results reveal distinct and shared female and male interaction-evoked patterns of male brain activation representing sex discrimination and social recognition. We also identify brain regions whose degree of activity correlates to specific features of social behaviors and estimate the total numbers and the densities of activated neurons per brain areas. Our study opens the door to automated screening of behavior-evoked brain activation in the mouse. |
| first_indexed | 2024-09-23T16:32:01Z |
| format | Article |
| id | mit-1721.1/101431 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:32:01Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1014312022-10-02T08:14:59Z Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse Kim, Yongsoo Venkataraju, Kannan Umadevi Pradhan, Kith Mende, Carolin Taranda, Julian Turaga, Srinivas C. Arganda-Carreras, Ignacio Ng, Lydia Hawrylycz, Michael J. Rockland, Kathleen S. Seung, H. Sebastian Osten, Pavel Turaga, Srinivas C. Seung, H. Sebastian Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Turaga, Srinivas C. Arganda-Carreras, Ignacio Seung, H. Sebastian Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping brain activation in the mouse in order to probe how sex-specific social behaviors are represented in the male brain. Our method uses the immediate-early-gene c-fos, a marker of neuronal activation, visualized by serial two-photon tomography: the c-fos-GFP+ neurons are computationally detected, their distribution is registered to a reference brain and a brain atlas, and their numbers are analyzed by statistical tests. Our results reveal distinct and shared female and male interaction-evoked patterns of male brain activation representing sex discrimination and social recognition. We also identify brain regions whose degree of activity correlates to specific features of social behaviors and estimate the total numbers and the densities of activated neurons per brain areas. Our study opens the door to automated screening of behavior-evoked brain activation in the mouse. Howard Hughes Medical Institute Gatsby Charitable Foundation 2016-03-03T03:26:30Z 2016-03-03T03:26:30Z 2014-12 2014-10 Article http://purl.org/eprint/type/JournalArticle 22111247 http://hdl.handle.net/1721.1/101431 Kim, Yongsoo, Kannan Umadevi Venkataraju, Kith Pradhan, Carolin Mende, Julian Taranda, Srinivas C. Turaga, Ignacio Arganda-Carreras, et al. “Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse.” Cell Reports 10, no. 2 (January 2015): 292–305. en_US http://dx.doi.org10.1016/j.celrep.2014.12.014 Cell Reports Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Kim, Yongsoo Venkataraju, Kannan Umadevi Pradhan, Kith Mende, Carolin Taranda, Julian Turaga, Srinivas C. Arganda-Carreras, Ignacio Ng, Lydia Hawrylycz, Michael J. Rockland, Kathleen S. Seung, H. Sebastian Osten, Pavel Turaga, Srinivas C. Seung, H. Sebastian Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse |
| title | Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse |
| title_full | Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse |
| title_fullStr | Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse |
| title_full_unstemmed | Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse |
| title_short | Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse |
| title_sort | mapping social behavior induced brain activation at cellular resolution in the mouse |
| url | http://hdl.handle.net/1721.1/101431 |
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