Molecular mechanism of force induced stabilization of collagen against enzymatic breakdown
Collagen cleavage, facilitated by collagenases of the matrix metalloproteinase (MMP) family, is crucial for many physiological and pathological processes such as wound healing, tissue remodeling, cancer invasion and organ morphogenesis. Earlier work has shown that mechanical force alters the cleavag...
Main Authors: | Chang, Shu-Wei, Flynn, Brendan P., Ruberti, Jeffrey W., Buehler, Markus J |
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Other Authors: | Massachusetts Institute of Technology. Center for Materials Science and Engineering |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2016
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Online Access: | http://hdl.handle.net/1721.1/101438 https://orcid.org/0000-0002-4173-9659 |
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