Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in hematological malignancies. Tet2 deletion in mice causes myeloid malignancies, while Tet1-null mice develop B cell lymphoma after an extended period o...

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Bibliographic Details
Main Authors: Zhao, Zhigang, Chen, Li, Dawlaty, Meelad M., Pan, Feng, Weeks, Ophelia, Zhou, Yuan, Cao, Zeng, Shi, Hui, Wang, Jiapeng, Lin, Li, Chen, Shi, Yuan, Weiping, Qin, Zhaohui, Ni, Hongyu, Nimer, Stephen D., Yang, Feng-Chun, Jaenisch, Rudolf, Jin, Peng, Xu, Mingjiang
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101657

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