Dissection of Axial-Pore Loop Function during Unfolding and Translocation by a AAA+ Proteolytic Machine
In the axial channels of ClpX and related hexameric AAA+ protein-remodeling rings, the pore-1 loops are thought to play important roles in engaging, mechanically unfolding, and translocating protein substrates. How these loops perform these functions and whether they also prevent substrate dissociat...
Main Authors: | Iosefson, Ohad, Olivares, Adrian O., Baker, Tania, Sauer, Robert T |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2016
|
Online Access: | http://hdl.handle.net/1721.1/101700 https://orcid.org/0000-0003-1710-9582 https://orcid.org/0000-0002-1719-5399 |
Similar Items
-
Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine
by: Aubin-Tam, Marie-Eve, et al.
Published: (2013) -
Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine
by: Iosefson, Ohad, et al.
Published: (2017) -
Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine
by: Cordova, Juan Carlos, et al.
Published: (2017) -
Mechanochemical basis of protein degradation by a double-ring AAA+ machine
by: Iosefson, Ohad, et al.
Published: (2015) -
Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine
by: Glynn, Steven E., et al.
Published: (2014)