Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota
The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify...
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| Format: | Članak |
| Jezik: | en_US |
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Elsevier
2016
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| Online pristup: | http://hdl.handle.net/1721.1/101707 https://orcid.org/0000-0002-0785-5410 |
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| author | Wang, Feng Kaplan, Jess L. Gold, Benjamin D. Bhasin, Manoj K. Ward, Naomi L. Kellermayer, Richard Kirschner, Barbara S. Heyman, Melvin B. Dowd, Scot E. Cox, Stephen B. Dogan, Haluk Steven, Blaire Ferry, George D. Cohen, Stanley A. Baldassano, Robert N. Moran, Christopher J. Garnett, Elizabeth A. Drake, Lauren Otu, Hasan H. Libermann, Towia A. Winter, Harland S. Korolev, Kirill S. Mirny, Leonid A |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Wang, Feng Kaplan, Jess L. Gold, Benjamin D. Bhasin, Manoj K. Ward, Naomi L. Kellermayer, Richard Kirschner, Barbara S. Heyman, Melvin B. Dowd, Scot E. Cox, Stephen B. Dogan, Haluk Steven, Blaire Ferry, George D. Cohen, Stanley A. Baldassano, Robert N. Moran, Christopher J. Garnett, Elizabeth A. Drake, Lauren Otu, Hasan H. Libermann, Towia A. Winter, Harland S. Korolev, Kirill S. Mirny, Leonid A |
| author_sort | Wang, Feng |
| collection | MIT |
| description | The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacterial taxa associated with pediatric Crohn disease and can detect significant changes in microbial communities with fewer samples than previous statistical approaches required. We have also substantially improved the accuracy of the diagnosis based on the microbiota from stool samples, and we found that the ecological niche of a microbe predicts its role in Crohn disease. Bacteria typically residing in the lumen of healthy individuals decrease in disease, whereas bacteria typically residing on the mucosa of healthy individuals increase in disease. Our results also show that the associations with Crohn disease are evolutionarily conserved and provide a mutual information-based method to depict dysbiosis. |
| first_indexed | 2024-09-23T09:29:48Z |
| format | Article |
| id | mit-1721.1/101707 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:29:48Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1017072022-09-30T14:49:51Z Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota Wang, Feng Kaplan, Jess L. Gold, Benjamin D. Bhasin, Manoj K. Ward, Naomi L. Kellermayer, Richard Kirschner, Barbara S. Heyman, Melvin B. Dowd, Scot E. Cox, Stephen B. Dogan, Haluk Steven, Blaire Ferry, George D. Cohen, Stanley A. Baldassano, Robert N. Moran, Christopher J. Garnett, Elizabeth A. Drake, Lauren Otu, Hasan H. Libermann, Towia A. Winter, Harland S. Korolev, Kirill S. Mirny, Leonid A Massachusetts Institute of Technology. Institute for Medical Engineering & Science Mirny, Leonid A. The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacterial taxa associated with pediatric Crohn disease and can detect significant changes in microbial communities with fewer samples than previous statistical approaches required. We have also substantially improved the accuracy of the diagnosis based on the microbiota from stool samples, and we found that the ecological niche of a microbe predicts its role in Crohn disease. Bacteria typically residing in the lumen of healthy individuals decrease in disease, whereas bacteria typically residing on the mucosa of healthy individuals increase in disease. Our results also show that the associations with Crohn disease are evolutionarily conserved and provide a mutual information-based method to depict dysbiosis. 2016-03-15T00:52:29Z 2016-03-15T00:52:29Z 2016-01 2015-12 Article http://purl.org/eprint/type/JournalArticle 22111247 http://hdl.handle.net/1721.1/101707 Wang, Feng, Jess L. Kaplan, Benjamin D. Gold, Manoj K. Bhasin, Naomi L. Ward, Richard Kellermayer, Barbara S. Kirschner, et al. “Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota.” Cell Reports 14, no. 4 (February 2016): 945–955. https://orcid.org/0000-0002-0785-5410 en_US http://dx.doi.org/10.1016/j.celrep.2015.12.088 Cell Reports Creative Commons Attribution http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Wang, Feng Kaplan, Jess L. Gold, Benjamin D. Bhasin, Manoj K. Ward, Naomi L. Kellermayer, Richard Kirschner, Barbara S. Heyman, Melvin B. Dowd, Scot E. Cox, Stephen B. Dogan, Haluk Steven, Blaire Ferry, George D. Cohen, Stanley A. Baldassano, Robert N. Moran, Christopher J. Garnett, Elizabeth A. Drake, Lauren Otu, Hasan H. Libermann, Towia A. Winter, Harland S. Korolev, Kirill S. Mirny, Leonid A Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota |
| title | Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota |
| title_full | Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota |
| title_fullStr | Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota |
| title_full_unstemmed | Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota |
| title_short | Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota |
| title_sort | detecting microbial dysbiosis associated with pediatric crohn disease despite the high variability of the gut microbiota |
| url | http://hdl.handle.net/1721.1/101707 https://orcid.org/0000-0002-0785-5410 |
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