Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention
The correlation between sleep integrity and attentional performance is normally interpreted as poor sleep causing impaired attention. Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing across sleep and attention, and their disruptio...
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| 格式: | 文件 |
| 语言: | en_US |
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Frontiers Research Foundation
2016
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| 在线阅读: | http://hdl.handle.net/1721.1/101719 https://orcid.org/0000-0001-7149-3584 |
| _version_ | 1826206355538575360 |
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| author | Chen, Zhe Wimmer, Ralf D. Wilson, Matthew A. Halassa, Michael M. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Chen, Zhe Wimmer, Ralf D. Wilson, Matthew A. Halassa, Michael M. |
| author_sort | Chen, Zhe |
| collection | MIT |
| description | The correlation between sleep integrity and attentional performance is normally interpreted as poor sleep causing impaired attention. Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing across sleep and attention, and their disruption may lead to correlated dysfunction. Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are predictive of their functional organization in sleep and suggestive of their participation in sensory processing across states. Surprisingly, TRN neurons associated with spindles in sleep are also associated with alpha oscillations during attention. As such, we propose that common thalamic circuit principles regulate sensory processing in a state-invariant manner and that in certain disorders, targeting these circuits may be a more viable therapeutic strategy than considering individual states in isolation. |
| first_indexed | 2024-09-23T13:27:53Z |
| format | Article |
| id | mit-1721.1/101719 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:27:53Z |
| publishDate | 2016 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/1017192022-09-28T14:29:38Z Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention Chen, Zhe Wimmer, Ralf D. Wilson, Matthew A. Halassa, Michael M. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Wilson, Matthew A. The correlation between sleep integrity and attentional performance is normally interpreted as poor sleep causing impaired attention. Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing across sleep and attention, and their disruption may lead to correlated dysfunction. Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are predictive of their functional organization in sleep and suggestive of their participation in sensory processing across states. Surprisingly, TRN neurons associated with spindles in sleep are also associated with alpha oscillations during attention. As such, we propose that common thalamic circuit principles regulate sensory processing in a state-invariant manner and that in certain disorders, targeting these circuits may be a more viable therapeutic strategy than considering individual states in isolation. National Institutes of Health (U.S.) (R01-MH06197) National Institutes of Health (U.S.) (TR01-GM10498) 2016-03-16T16:54:39Z 2016-03-16T16:54:39Z 2016-01 2015-09 Article http://purl.org/eprint/type/JournalArticle 1662-5110 http://hdl.handle.net/1721.1/101719 Chen, Zhe, Ralf D. Wimmer, Matthew A. Wilson, and Michael M. Halassa. “Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention.” Front. Neural Circuits 9 (January 5, 2016). https://orcid.org/0000-0001-7149-3584 en_US http://dx.doi.org/10.3389/fncir.2015.00083 Frontiers in Neural Circuits Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers Research Foundation |
| spellingShingle | Chen, Zhe Wimmer, Ralf D. Wilson, Matthew A. Halassa, Michael M. Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention |
| title | Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention |
| title_full | Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention |
| title_fullStr | Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention |
| title_full_unstemmed | Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention |
| title_short | Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention |
| title_sort | thalamic circuit mechanisms link sensory processing in sleep and attention |
| url | http://hdl.handle.net/1721.1/101719 https://orcid.org/0000-0001-7149-3584 |
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