Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of...
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2016
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| Online Access: | http://hdl.handle.net/1721.1/101727 |
| _version_ | 1826198588280012800 |
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| author | Waterhouse, Robert |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Waterhouse, Robert |
| author_sort | Waterhouse, Robert |
| collection | MIT |
| description | The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite. |
| first_indexed | 2024-09-23T11:06:50Z |
| format | Article |
| id | mit-1721.1/101727 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:06:50Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1017272022-10-01T01:21:30Z Unique features of a global human ectoparasite identified through sequencing of the bed bug genome Waterhouse, Robert Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Waterhouse, Robert The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite. Marie Curie International Fellowship (PIOF-GA-2011–303312) 2016-03-16T23:50:59Z 2016-03-16T23:50:59Z 2016-02 2015-04 Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/101727 Benoit, Joshua B., Zach N. Adelman, Klaus Reinhardt, Amanda Dolan, Monica Poelchau, Emily C. Jennings, Elise M. Szuter, et al. “Unique Features of a Global Human Ectoparasite Identified through Sequencing of the Bed Bug Genome.” Nat Comms 7 (February 2, 2016): 10165. en_US http://dx.doi.org/10.1038/ncomms10165 Nature Communications Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature Publishing Group |
| spellingShingle | Waterhouse, Robert Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_full | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_fullStr | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_full_unstemmed | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_short | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_sort | unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| url | http://hdl.handle.net/1721.1/101727 |
| work_keys_str_mv | AT waterhouserobert uniquefeaturesofaglobalhumanectoparasiteidentifiedthroughsequencingofthebedbuggenome |