Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells
A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible...
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| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell
2016
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| Online Access: | http://hdl.handle.net/1721.1/101769 https://orcid.org/0000-0001-6070-7356 |
| _version_ | 1811095087471394816 |
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| author | Aceto, Nicola Lim, Eugene J. Sullivan, James P. Jensen, Anne E. Zeinali, Mahnaz Martel, Joseph M. Aranyosi, Alexander J. Li, Wei Castleberry, Steven Bardia, Aditya Sequist, Lecia V. Haber, Daniel A. Maheswaran, Shyamala Hammond, Paula T. Toner, Mehmet Stott, Shannon L. Reategui, Eduardo |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Aceto, Nicola Lim, Eugene J. Sullivan, James P. Jensen, Anne E. Zeinali, Mahnaz Martel, Joseph M. Aranyosi, Alexander J. Li, Wei Castleberry, Steven Bardia, Aditya Sequist, Lecia V. Haber, Daniel A. Maheswaran, Shyamala Hammond, Paula T. Toner, Mehmet Stott, Shannon L. Reategui, Eduardo |
| author_sort | Aceto, Nicola |
| collection | MIT |
| description | A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. |
| first_indexed | 2024-09-23T16:10:26Z |
| format | Article |
| id | mit-1721.1/101769 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:10:26Z |
| publishDate | 2016 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1017692022-09-29T18:45:42Z Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells Aceto, Nicola Lim, Eugene J. Sullivan, James P. Jensen, Anne E. Zeinali, Mahnaz Martel, Joseph M. Aranyosi, Alexander J. Li, Wei Castleberry, Steven Bardia, Aditya Sequist, Lecia V. Haber, Daniel A. Maheswaran, Shyamala Hammond, Paula T. Toner, Mehmet Stott, Shannon L. Reategui, Eduardo Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Lim, Eugene J. Li, Wei Castleberry, Steven Hammond, Paula T. A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. 2016-03-24T15:05:39Z 2016-03-24T15:05:39Z 2015-01 2014-12 Article http://purl.org/eprint/type/JournalArticle 09359648 1521-4095 http://hdl.handle.net/1721.1/101769 Reategui, Eduardo, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne E. Jensen, Mahnaz Zeinali, Joseph M. Martel, et al. “Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells.” Advanced Materials 27, no. 9 (January 15, 2015): 1593–1599. https://orcid.org/0000-0001-6070-7356 en_US http://dx.doi.org/10.1002/adma.201404677 Advanced Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Aceto, Nicola Lim, Eugene J. Sullivan, James P. Jensen, Anne E. Zeinali, Mahnaz Martel, Joseph M. Aranyosi, Alexander J. Li, Wei Castleberry, Steven Bardia, Aditya Sequist, Lecia V. Haber, Daniel A. Maheswaran, Shyamala Hammond, Paula T. Toner, Mehmet Stott, Shannon L. Reategui, Eduardo Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells |
| title | Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells |
| title_full | Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells |
| title_fullStr | Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells |
| title_full_unstemmed | Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells |
| title_short | Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells |
| title_sort | tunable nanostructured coating for the capture and selective release of viable circulating tumor cells |
| url | http://hdl.handle.net/1721.1/101769 https://orcid.org/0000-0001-6070-7356 |
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