HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages
High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting capability as well as the option to incorporate lipophilic payloads, e.g., imaging or therapeutic components, in both the hydrophobic core and th...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2016
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| Online Access: | http://hdl.handle.net/1721.1/101770 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826213561524813824 |
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| author | Sanchez-Gaytan, Brenda L. Fay, Francois Lobatto, Mark E. Tang, Jun Ouimet, Mireille Kim, YongTae van der Staay, Susanne E. M. van Rijs, Sarian M. Priem, Bram Zhang, Liangfang Fisher, Edward A. Moore, Kathryn J. Fayad, Zahi A. Mulder, Willem J. M. Langer, Robert S |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Sanchez-Gaytan, Brenda L. Fay, Francois Lobatto, Mark E. Tang, Jun Ouimet, Mireille Kim, YongTae van der Staay, Susanne E. M. van Rijs, Sarian M. Priem, Bram Zhang, Liangfang Fisher, Edward A. Moore, Kathryn J. Fayad, Zahi A. Mulder, Willem J. M. Langer, Robert S |
| author_sort | Sanchez-Gaytan, Brenda L. |
| collection | MIT |
| description | High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting capability as well as the option to incorporate lipophilic payloads, e.g., imaging or therapeutic components, in both the hydrophobic core and the phospholipid corona make the HDL platform an attractive nanocarrier. To realize controlled release properties, we developed a hybrid polymer/HDL nanoparticle composed of a lipid/apolipoprotein coating that encapsulates a poly(lactic-co-glycolic acid) (PLGA) core. This novel HDL-like nanoparticle (PLGA–HDL) displayed natural HDL characteristics, including preferential uptake by macrophages and a good cholesterol efflux capacity, combined with a typical PLGA nanoparticle slow release profile. In vivo studies carried out with an ApoE knockout mouse model of atherosclerosis showed clear accumulation of PLGA–HDL nanoparticles in atherosclerotic plaques, which colocalized with plaque macrophages. This biomimetic platform integrates the targeting capacity of HDL biomimetic nanoparticles with the characteristic versatility of PLGA-based nanocarriers. |
| first_indexed | 2024-09-23T15:51:12Z |
| format | Article |
| id | mit-1721.1/101770 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:51:12Z |
| publishDate | 2016 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1017702022-10-02T04:37:54Z HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages Sanchez-Gaytan, Brenda L. Fay, Francois Lobatto, Mark E. Tang, Jun Ouimet, Mireille Kim, YongTae van der Staay, Susanne E. M. van Rijs, Sarian M. Priem, Bram Zhang, Liangfang Fisher, Edward A. Moore, Kathryn J. Fayad, Zahi A. Mulder, Willem J. M. Langer, Robert S Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Langer, Robert High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting capability as well as the option to incorporate lipophilic payloads, e.g., imaging or therapeutic components, in both the hydrophobic core and the phospholipid corona make the HDL platform an attractive nanocarrier. To realize controlled release properties, we developed a hybrid polymer/HDL nanoparticle composed of a lipid/apolipoprotein coating that encapsulates a poly(lactic-co-glycolic acid) (PLGA) core. This novel HDL-like nanoparticle (PLGA–HDL) displayed natural HDL characteristics, including preferential uptake by macrophages and a good cholesterol efflux capacity, combined with a typical PLGA nanoparticle slow release profile. In vivo studies carried out with an ApoE knockout mouse model of atherosclerosis showed clear accumulation of PLGA–HDL nanoparticles in atherosclerotic plaques, which colocalized with plaque macrophages. This biomimetic platform integrates the targeting capacity of HDL biomimetic nanoparticles with the characteristic versatility of PLGA-based nanocarriers. National Institutes of Health (U.S.) (National Heart, Lung, and Blood Institute Program of Excellence in Nanotechnology Award Contract HHSN268201000045C) 2016-03-24T15:18:34Z 2016-03-24T15:18:34Z 2015-02 2015-01 Article http://purl.org/eprint/type/JournalArticle 1043-1802 1520-4812 http://hdl.handle.net/1721.1/101770 Sanchez-Gaytan, Brenda L., Francois Fay, Mark E. Lobatto, Jun Tang, Mireille Ouimet, YongTae Kim, Susanne E. M. van der Staay, et al. “HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages.” Bioconjugate Chemistry 26, no. 3 (March 18, 2015): 443–451. https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1021/bc500517k Bioconjugate Chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Sanchez-Gaytan, Brenda L. Fay, Francois Lobatto, Mark E. Tang, Jun Ouimet, Mireille Kim, YongTae van der Staay, Susanne E. M. van Rijs, Sarian M. Priem, Bram Zhang, Liangfang Fisher, Edward A. Moore, Kathryn J. Fayad, Zahi A. Mulder, Willem J. M. Langer, Robert S HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages |
| title | HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages |
| title_full | HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages |
| title_fullStr | HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages |
| title_full_unstemmed | HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages |
| title_short | HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages |
| title_sort | hdl mimetic plga nanoparticle to target atherosclerosis plaque macrophages |
| url | http://hdl.handle.net/1721.1/101770 https://orcid.org/0000-0003-4255-0492 |
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