A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

We show that a common polymorphic variant in the ERCC5 5′ untranslated region (UTR) generates an upstream ORF (uORF) that affects both the background expression of this protein and its ability to be synthesized following exposure to agents that cause bulky adduct DNA damage. Individuals that harbor...

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Bibliographic Details
Main Authors: Somers, Joanna, Wilson, Lindsay A., Kilday, John-Paul, Horvilleur, Emilie, Cobbold, Laura C., Kondrashov, Alexander, Grill, Jacques, Grundy, Richard G., Bushell, Martin, Willis, Anne E., Poyry, Tuija A. A., Puget, Stephanie, Knight, John R. P., Cannell, Ian Gordon
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2016
Online Access:http://hdl.handle.net/1721.1/102088

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