An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection
Background Deficits in social cognition, including impairments in self-awareness, contribute to the overall functional disability associated with schizophrenia. Studies in healthy subjects have shown that social cognitive functions, including self-reflection, rely on the medial prefrontal cortex (m...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
|
| Online Access: | http://hdl.handle.net/1721.1/102183 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1811083139238330368 |
|---|---|
| author | Holt, Daphne J. Cassidy, Brittany S. Andrews-Hanna, Jessica R. Lee, Su Mei Coombs, Garth Goff, Donald C. Moran, Joseph M. Gabrieli, John D. E. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Holt, Daphne J. Cassidy, Brittany S. Andrews-Hanna, Jessica R. Lee, Su Mei Coombs, Garth Goff, Donald C. Moran, Joseph M. Gabrieli, John D. E. |
| author_sort | Holt, Daphne J. |
| collection | MIT |
| description | Background
Deficits in social cognition, including impairments in self-awareness, contribute to the overall functional disability associated with schizophrenia. Studies in healthy subjects have shown that social cognitive functions, including self-reflection, rely on the medial prefrontal cortex (mPFC) and posterior cingulate gyrus, and these regions exhibit highly correlated activity during “resting” states. In this study, we tested the hypothesis that patients with schizophrenia show dysfunction of this network during self-reflection and that this abnormal activity is associated with changes in the strength of resting-state correlations between these regions.
Methods
Activation during self-reflection and control tasks was measured with functional magnetic resonance imaging in 19 patients with schizophrenia and 20 demographically matched control subjects. In addition, the resting-state functional connectivity of midline cortical areas showing abnormal self-reflection-related activation in schizophrenia was measured.
Results
Compared with control subjects, the schizophrenia patients demonstrated lower activation of the right ventral mPFC and greater activation of the mid/posterior cingulate gyri bilaterally during self-reflection, relative to a control task. A similar pattern was seen during overall social reflection. In addition, functional connectivity between the portion of the left mid/posterior cingulate gyrus showing abnormally elevated activity during self-reflection in schizophrenia, and the dorsal anterior cingulate gyrus was lower in the schizophrenia patients compared with control subjects.
Conclusions
Schizophrenia is associated with an anterior-to-posterior shift in introspection-related activation, as well as changes in functional connectivity, of the midline cortex. These findings provide support for the hypothesis that aberrant midline cortical function contributes to social cognitive impairment in schizophrenia. |
| first_indexed | 2024-09-23T12:24:23Z |
| format | Article |
| id | mit-1721.1/102183 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:24:23Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1021832022-10-01T09:07:37Z An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection Holt, Daphne J. Cassidy, Brittany S. Andrews-Hanna, Jessica R. Lee, Su Mei Coombs, Garth Goff, Donald C. Moran, Joseph M. Gabrieli, John D. E. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Lee, Su Mei Gabrieli, John D. E. Moran, Joseph M. Background Deficits in social cognition, including impairments in self-awareness, contribute to the overall functional disability associated with schizophrenia. Studies in healthy subjects have shown that social cognitive functions, including self-reflection, rely on the medial prefrontal cortex (mPFC) and posterior cingulate gyrus, and these regions exhibit highly correlated activity during “resting” states. In this study, we tested the hypothesis that patients with schizophrenia show dysfunction of this network during self-reflection and that this abnormal activity is associated with changes in the strength of resting-state correlations between these regions. Methods Activation during self-reflection and control tasks was measured with functional magnetic resonance imaging in 19 patients with schizophrenia and 20 demographically matched control subjects. In addition, the resting-state functional connectivity of midline cortical areas showing abnormal self-reflection-related activation in schizophrenia was measured. Results Compared with control subjects, the schizophrenia patients demonstrated lower activation of the right ventral mPFC and greater activation of the mid/posterior cingulate gyri bilaterally during self-reflection, relative to a control task. A similar pattern was seen during overall social reflection. In addition, functional connectivity between the portion of the left mid/posterior cingulate gyrus showing abnormally elevated activity during self-reflection in schizophrenia, and the dorsal anterior cingulate gyrus was lower in the schizophrenia patients compared with control subjects. Conclusions Schizophrenia is associated with an anterior-to-posterior shift in introspection-related activation, as well as changes in functional connectivity, of the midline cortex. These findings provide support for the hypothesis that aberrant midline cortical function contributes to social cognitive impairment in schizophrenia. Poitras Center for Affective Disorders Research 2016-04-06T17:17:02Z 2016-04-06T17:17:02Z 2010-12 2010-10 Article http://purl.org/eprint/type/JournalArticle 00063223 http://hdl.handle.net/1721.1/102183 Holt, Daphne J., Brittany S. Cassidy, Jessica R. Andrews-Hanna, Su Mei Lee, Garth Coombs, Donald C. Goff, John D. Gabrieli, and Joseph M. Moran. “An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection.” Biological Psychiatry 69, no. 5 (March 2011): 415–423. https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1016/j.biopsych.2010.10.003 Biological Psychiatry Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Holt, Daphne J. Cassidy, Brittany S. Andrews-Hanna, Jessica R. Lee, Su Mei Coombs, Garth Goff, Donald C. Moran, Joseph M. Gabrieli, John D. E. An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection |
| title | An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection |
| title_full | An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection |
| title_fullStr | An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection |
| title_full_unstemmed | An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection |
| title_short | An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection |
| title_sort | anterior to posterior shift in midline cortical activity in schizophrenia during self reflection |
| url | http://hdl.handle.net/1721.1/102183 https://orcid.org/0000-0003-1158-5692 |
| work_keys_str_mv | AT holtdaphnej ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT cassidybrittanys ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT andrewshannajessicar ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT leesumei ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT coombsgarth ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT goffdonaldc ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT moranjosephm ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT gabrielijohnde ananteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT holtdaphnej anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT cassidybrittanys anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT andrewshannajessicar anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT leesumei anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT coombsgarth anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT goffdonaldc anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT moranjosephm anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection AT gabrielijohnde anteriortoposteriorshiftinmidlinecorticalactivityinschizophreniaduringselfreflection |