The contribution of GABAergic dysfunction to neurodevelopmental disorders
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The GABAergic system is indispensable for maintaining the balance between excitation and inhibition (E/I balance) required for normal neural circuit function. E/I imbalances that result from perturbations in the develo...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102223 https://orcid.org/0000-0002-7002-1275 |
| _version_ | 1826214098266750976 |
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| author | Ramamoorthi, Kartik Lin, Yingxi |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Ramamoorthi, Kartik Lin, Yingxi |
| author_sort | Ramamoorthi, Kartik |
| collection | MIT |
| description | GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The GABAergic system is indispensable for maintaining the balance between excitation and inhibition (E/I balance) required for normal neural circuit function. E/I imbalances that result from perturbations in the development of this system, ranging from the generation of inhibitory neurons to the formation of their synaptic connections, have been implicated in several neurodevelopmental disorders. In this review, we discuss how impairments at different stages in GABAergic development can lead to disease states. We also highlight recent studies which show that modulation of the GABAergic system can successfully reverse cognitive deficits in disease models and suggest that therapeutic strategies targeting the GABAergic system could be effective in treating neurodevelopmental disorders. |
| first_indexed | 2024-09-23T15:59:28Z |
| format | Article |
| id | mit-1721.1/102223 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:59:28Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1022232022-10-02T05:36:39Z The contribution of GABAergic dysfunction to neurodevelopmental disorders Ramamoorthi, Kartik Lin, Yingxi Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Ramamoorthi, Kartik Lin, Yingxi GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The GABAergic system is indispensable for maintaining the balance between excitation and inhibition (E/I balance) required for normal neural circuit function. E/I imbalances that result from perturbations in the development of this system, ranging from the generation of inhibitory neurons to the formation of their synaptic connections, have been implicated in several neurodevelopmental disorders. In this review, we discuss how impairments at different stages in GABAergic development can lead to disease states. We also highlight recent studies which show that modulation of the GABAergic system can successfully reverse cognitive deficits in disease models and suggest that therapeutic strategies targeting the GABAergic system could be effective in treating neurodevelopmental disorders. McGovern Institute for Brain Research at MIT MIT Presidential Marcus Fellowship to Honor Norman B. Leventhal Whitehall Foundation (Research Grant) John Merck Fund Massachusetts Institute of Technology. James H. Ferry Fund Simons Foundation. Autism Research Initiative National Institutes of Health (U.S.) (Grant MH091220-01) 2016-04-08T16:44:56Z 2016-04-08T16:44:56Z 2011-04 Article http://purl.org/eprint/type/JournalArticle 14714914 http://hdl.handle.net/1721.1/102223 Ramamoorthi, Kartik, and Yingxi Lin. “The Contribution of GABAergic Dysfunction to Neurodevelopmental Disorders.” Trends in Molecular Medicine 17, no. 8 (August 2011): 452–462. https://orcid.org/0000-0002-7002-1275 en_US http://dx.doi.org/10.1016/j.molmed.2011.03.003 Trends in Molecular Medicine Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Ramamoorthi, Kartik Lin, Yingxi The contribution of GABAergic dysfunction to neurodevelopmental disorders |
| title | The contribution of GABAergic dysfunction to neurodevelopmental disorders |
| title_full | The contribution of GABAergic dysfunction to neurodevelopmental disorders |
| title_fullStr | The contribution of GABAergic dysfunction to neurodevelopmental disorders |
| title_full_unstemmed | The contribution of GABAergic dysfunction to neurodevelopmental disorders |
| title_short | The contribution of GABAergic dysfunction to neurodevelopmental disorders |
| title_sort | contribution of gabaergic dysfunction to neurodevelopmental disorders |
| url | http://hdl.handle.net/1721.1/102223 https://orcid.org/0000-0002-7002-1275 |
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