A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex
Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the ne...
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| 格式: | 文件 |
| 语言: | en_US |
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Elsevier
2016
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| 在线阅读: | http://hdl.handle.net/1721.1/102249 |
| _version_ | 1826214521889357824 |
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| author | Chubykin, Alexander A. Roach, Emma B. Shuler, Marshall G. Hussain Bear, Mark Chubykin, Alexander A. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Chubykin, Alexander A. Roach, Emma B. Shuler, Marshall G. Hussain Bear, Mark Chubykin, Alexander A. |
| author_sort | Chubykin, Alexander A. |
| collection | MIT |
| description | Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the neural acquisition, but not the expression, of reward timing in the visual cortex of awake, behaving animals. We then mimic reward timing in vitro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and show that this protocol results in the prolongation of electrically evoked spike train durations out to the conditioned interval. Together, these data suggest that V1 possesses the circuitry and plasticity to support reward time prediction learning and the cholinergic system serves as an important reinforcement signal which, in vivo, conveys to the cortex the outcome of behavior. |
| first_indexed | 2024-09-23T16:07:05Z |
| format | Article |
| id | mit-1721.1/102249 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:07:05Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1022492022-09-29T18:19:33Z A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex Chubykin, Alexander A. Roach, Emma B. Shuler, Marshall G. Hussain Bear, Mark Chubykin, Alexander A. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Chubykin, Alexander A. Bear, Mark Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the neural acquisition, but not the expression, of reward timing in the visual cortex of awake, behaving animals. We then mimic reward timing in vitro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and show that this protocol results in the prolongation of electrically evoked spike train durations out to the conditioned interval. Together, these data suggest that V1 possesses the circuitry and plasticity to support reward time prediction learning and the cholinergic system serves as an important reinforcement signal which, in vivo, conveys to the cortex the outcome of behavior. National Eye Institute (Grant R01 EYO12309) Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (Grant R01 HD046943) 2016-04-15T20:15:02Z 2016-04-15T20:15:02Z 2013-02 Article http://purl.org/eprint/type/JournalArticle 08966273 1097-4199 http://hdl.handle.net/1721.1/102249 Chubykin, Alexander A., Emma B. Roach, Mark F. Bear, and Marshall G. Hussain Shuler. “A Cholinergic Mechanism for Reward Timing Within Primary Visual Cortex.” Neuron 77, no. 4 (February 2013): 723–735. en_US http://dx.doi.org/10.1016/j.neuron.2012.12.039 Neuron Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Chubykin, Alexander A. Roach, Emma B. Shuler, Marshall G. Hussain Bear, Mark Chubykin, Alexander A. A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex |
| title | A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex |
| title_full | A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex |
| title_fullStr | A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex |
| title_full_unstemmed | A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex |
| title_short | A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex |
| title_sort | cholinergic mechanism for reward timing within primary visual cortex |
| url | http://hdl.handle.net/1721.1/102249 |
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