Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome
Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102250 https://orcid.org/0000-0003-0582-2284 |
| _version_ | 1811072929293664256 |
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| author | Chuang, Shih-Chieh Chubykin, Alexander A. Sidorov, Michael Bianchi, Riccardo Wong, Robert K.S. Osterweil, Emily Bear, Mark Chubykin, Alexander A. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Chuang, Shih-Chieh Chubykin, Alexander A. Sidorov, Michael Bianchi, Riccardo Wong, Robert K.S. Osterweil, Emily Bear, Mark Chubykin, Alexander A. |
| author_sort | Chuang, Shih-Chieh |
| collection | MIT |
| description | Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis in the mouse model of FXS and can prevent one of the robust functional consequences of increased protein synthesis in FXS, epileptogenesis. These data suggest that lovastatin is potentially disease modifying and could be a viable prophylactic treatment for epileptogenesis in FXS. |
| first_indexed | 2024-09-23T09:22:25Z |
| format | Article |
| id | mit-1721.1/102250 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:22:25Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1022502022-09-26T11:20:00Z Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome Chuang, Shih-Chieh Chubykin, Alexander A. Sidorov, Michael Bianchi, Riccardo Wong, Robert K.S. Osterweil, Emily Bear, Mark Chubykin, Alexander A. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Osterweil, Emily Chubykin, Alexander A. Sidorov, Michael Bear, Mark Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis in the mouse model of FXS and can prevent one of the robust functional consequences of increased protein synthesis in FXS, epileptogenesis. These data suggest that lovastatin is potentially disease modifying and could be a viable prophylactic treatment for epileptogenesis in FXS. FRAXA Research Foundation National Institute of Mental Health (U.S.) Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) Simons Foundation 2016-04-15T20:28:47Z 2016-04-15T20:28:47Z 2013-01 Article http://purl.org/eprint/type/JournalArticle 08966273 1097-4199 http://hdl.handle.net/1721.1/102250 Osterweil, Emily K., Shih-Chieh Chuang, Alexander A. Chubykin, Michael Sidorov, Riccardo Bianchi, Robert K.S. Wong, and Mark F. Bear. “Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome.” Neuron 77, no. 2 (January 2013): 243–250. https://orcid.org/0000-0003-0582-2284 en_US http://dx.doi.org/10.1016/j.neuron.2012.01.034 Neuron Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Chuang, Shih-Chieh Chubykin, Alexander A. Sidorov, Michael Bianchi, Riccardo Wong, Robert K.S. Osterweil, Emily Bear, Mark Chubykin, Alexander A. Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome |
| title | Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome |
| title_full | Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome |
| title_fullStr | Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome |
| title_full_unstemmed | Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome |
| title_short | Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome |
| title_sort | lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile x syndrome |
| url | http://hdl.handle.net/1721.1/102250 https://orcid.org/0000-0003-0582-2284 |
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