Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale
Recent studies of micro- and nano-scale mechanics of cartilage and chondrocyte pericellular matrix have begun to relate matrix molecular structure to its mechanical response. AFM-based indentation has revealed rate-dependent stiffness at the micro-scale. While multi-scale elastic behavior has been s...
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| Format: | Article |
| Language: | en_US |
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Orthopaedic Research Society
2016
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| Online Access: | http://hdl.handle.net/1721.1/102268 https://orcid.org/0000-0003-3511-5679 https://orcid.org/0000-0003-1970-9901 https://orcid.org/0000-0002-4942-3456 |
| _version_ | 1826202550810968064 |
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| author | Tavakoli Nia, Hadi Han, L. Li, Y. Ortiz, Christine Grodzinsky, Alan J. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Tavakoli Nia, Hadi Han, L. Li, Y. Ortiz, Christine Grodzinsky, Alan J. |
| author_sort | Tavakoli Nia, Hadi |
| collection | MIT |
| description | Recent studies of micro- and nano-scale mechanics of cartilage and chondrocyte pericellular matrix have begun to relate matrix molecular structure to its mechanical response. AFM-based indentation has revealed rate-dependent stiffness at the micro-scale. While multi-scale elastic behavior has been studied, and poro-viscoelastic properties have been extensively documented at the tissue-level, time-dependent behavior and energy dissipation mechanisms of cartilage matrix at the nano-scale are not well understood. Here, we used AFM-based dynamic compression in conjunction with poroelastic finite element modeling to study the frequency-dependent behavior of cartilage using nano-scale oscillatory displacement amplitudes. We introduce the characteristic frequency f[subscript peak] at which the maximum energy dissipation occurs as an important parameter to characterize matrix time-dependent behavior. Use of micron-sized AFM probe tips with nano-scale oscillatory displacements over a 3-decade frequency range enabled clear identification of this characteristic frequency f[subscript peak]. The length-scale dependence of poroelastic behavior combined with judicious choice of probe tip geometry revealed flow-dependent and flow-independent behavior during matrix displacement amplitudes on the order of macromolecular dimensions and intermolecular pore-sizes. |
| first_indexed | 2024-09-23T12:09:16Z |
| format | Article |
| id | mit-1721.1/102268 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:09:16Z |
| publishDate | 2016 |
| publisher | Orthopaedic Research Society |
| record_format | dspace |
| spelling | mit-1721.1/1022682022-09-28T00:33:51Z Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale Tavakoli Nia, Hadi Han, L. Li, Y. Ortiz, Christine Grodzinsky, Alan J. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Ortiz, Christine Tavakoli Nia, Hadi Han, L. Li, Y. Ortiz, Christine Grodzinsky, Alan J. Recent studies of micro- and nano-scale mechanics of cartilage and chondrocyte pericellular matrix have begun to relate matrix molecular structure to its mechanical response. AFM-based indentation has revealed rate-dependent stiffness at the micro-scale. While multi-scale elastic behavior has been studied, and poro-viscoelastic properties have been extensively documented at the tissue-level, time-dependent behavior and energy dissipation mechanisms of cartilage matrix at the nano-scale are not well understood. Here, we used AFM-based dynamic compression in conjunction with poroelastic finite element modeling to study the frequency-dependent behavior of cartilage using nano-scale oscillatory displacement amplitudes. We introduce the characteristic frequency f[subscript peak] at which the maximum energy dissipation occurs as an important parameter to characterize matrix time-dependent behavior. Use of micron-sized AFM probe tips with nano-scale oscillatory displacements over a 3-decade frequency range enabled clear identification of this characteristic frequency f[subscript peak]. The length-scale dependence of poroelastic behavior combined with judicious choice of probe tip geometry revealed flow-dependent and flow-independent behavior during matrix displacement amplitudes on the order of macromolecular dimensions and intermolecular pore-sizes. National Science Foundation (U.S.) (Grant CMMI-0758651) National Institutes of Health (U.S.) (National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.) Grant AR33236) 2016-04-19T17:53:06Z 2016-04-19T17:53:06Z 2011-01 Article http://purl.org/eprint/type/ConferencePaper http://hdl.handle.net/1721.1/102268 Tavakoli Nia, H., L. Han, Y. Li, C. Ortiz, and A. Grodzinsky. "Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale." 2011 Orthopaedic Research Society Annual Meeting (January 2011). https://orcid.org/0000-0003-3511-5679 https://orcid.org/0000-0003-1970-9901 https://orcid.org/0000-0002-4942-3456 en_US www.ors.org Proceedings of the 2011 Orthopaedic Research Society Annual Meeting Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Orthopaedic Research Society Prof. Ortiz via Angie Locknar |
| spellingShingle | Tavakoli Nia, Hadi Han, L. Li, Y. Ortiz, Christine Grodzinsky, Alan J. Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale |
| title | Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale |
| title_full | Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale |
| title_fullStr | Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale |
| title_full_unstemmed | Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale |
| title_short | Poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano-scale |
| title_sort | poroelasticity is the dominant energy dissipation mechanism in cartilage at the nano scale |
| url | http://hdl.handle.net/1721.1/102268 https://orcid.org/0000-0003-3511-5679 https://orcid.org/0000-0003-1970-9901 https://orcid.org/0000-0002-4942-3456 |
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