Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Optical Society of America
2016
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| Online Access: | http://hdl.handle.net/1721.1/102405 |
| _version_ | 1826189188888788992 |
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| author | Tian, Fei Min, Jouha Kanka, Jiri Li, Xiangzhi Du, Henry Hammond, Paula T |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Tian, Fei Min, Jouha Kanka, Jiri Li, Xiangzhi Du, Henry Hammond, Paula T |
| author_sort | Tian, Fei |
| collection | MIT |
| description | A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions. |
| first_indexed | 2024-09-23T08:11:15Z |
| format | Article |
| id | mit-1721.1/102405 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:11:15Z |
| publishDate | 2016 |
| publisher | Optical Society of America |
| record_format | dspace |
| spelling | mit-1721.1/1024052022-09-30T08:10:15Z Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers Tian, Fei Min, Jouha Kanka, Jiri Li, Xiangzhi Du, Henry Hammond, Paula T Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Hammond, Paula T. Min, Jouha Hammond, Paula T. A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions. National Science Foundation (U.S.) (Grant DMR-1206669) Czech Republic. Ministry of Education, Youth, and Sports (Grant LH 11038) 2016-05-04T17:49:11Z 2016-05-04T17:49:11Z 2015-07 2015-07 Article http://purl.org/eprint/type/JournalArticle 1094-4087 http://hdl.handle.net/1721.1/102405 Tian, Fei, Jouha Min, Jiri Kanka, Xiangzhi Li, Paula T. Hammond, and Henry Du. “Lab-on-Fiber Optofluidic Platform for in Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers.” Optics Express 23, no. 15 (July 24, 2015): 20132. en_US http://dx.doi.org/10.1364/oe.23.020132 Optics Express Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Optical Society of America Prof. Hammond via Erja Kajosalo |
| spellingShingle | Tian, Fei Min, Jouha Kanka, Jiri Li, Xiangzhi Du, Henry Hammond, Paula T Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| title | Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| title_full | Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| title_fullStr | Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| title_full_unstemmed | Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| title_short | Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| title_sort | lab on fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers |
| url | http://hdl.handle.net/1721.1/102405 |
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