Flow of Cortical Activity Underlying a Tactile Decision in Mice
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A s...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
|
| Online Access: | http://hdl.handle.net/1721.1/102406 https://orcid.org/0000-0002-8021-277X |
| _version_ | 1826206540980289536 |
|---|---|
| author | Guo, Zengcai V. Li, Nuo Huber, Daniel Ophir, Eran Gutnisky, Diego Feng, Guoping Svoboda, Karel Ting, Jonathan Thomas |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Guo, Zengcai V. Li, Nuo Huber, Daniel Ophir, Eran Gutnisky, Diego Feng, Guoping Svoboda, Karel Ting, Jonathan Thomas |
| author_sort | Guo, Zengcai V. |
| collection | MIT |
| description | Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile “sensation” and “action” (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making. |
| first_indexed | 2024-09-23T13:34:34Z |
| format | Article |
| id | mit-1721.1/102406 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:34:34Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1024062022-10-01T15:48:35Z Flow of Cortical Activity Underlying a Tactile Decision in Mice Guo, Zengcai V. Li, Nuo Huber, Daniel Ophir, Eran Gutnisky, Diego Feng, Guoping Svoboda, Karel Ting, Jonathan Thomas Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Ting, Jonathan Thomas Feng, Guoping Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile “sensation” and “action” (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making. Howard Hughes Medical Institute 2016-05-04T22:37:56Z 2016-05-04T22:37:56Z 2013-12 Article http://purl.org/eprint/type/JournalArticle 08966273 http://hdl.handle.net/1721.1/102406 Guo, Zengcai V., Nuo Li, Daniel Huber, Eran Ophir, Diego Gutnisky, Jonathan T. Ting, Guoping Feng, and Karel Svoboda. “Flow of Cortical Activity Underlying a Tactile Decision in Mice.” Neuron 81, no. 1 (January 2014): 179–194. https://orcid.org/0000-0002-8021-277X en_US http://dx.doi.org/10.1016/j.neuron.2013.10.020 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Guo, Zengcai V. Li, Nuo Huber, Daniel Ophir, Eran Gutnisky, Diego Feng, Guoping Svoboda, Karel Ting, Jonathan Thomas Flow of Cortical Activity Underlying a Tactile Decision in Mice |
| title | Flow of Cortical Activity Underlying a Tactile Decision in Mice |
| title_full | Flow of Cortical Activity Underlying a Tactile Decision in Mice |
| title_fullStr | Flow of Cortical Activity Underlying a Tactile Decision in Mice |
| title_full_unstemmed | Flow of Cortical Activity Underlying a Tactile Decision in Mice |
| title_short | Flow of Cortical Activity Underlying a Tactile Decision in Mice |
| title_sort | flow of cortical activity underlying a tactile decision in mice |
| url | http://hdl.handle.net/1721.1/102406 https://orcid.org/0000-0002-8021-277X |
| work_keys_str_mv | AT guozengcaiv flowofcorticalactivityunderlyingatactiledecisioninmice AT linuo flowofcorticalactivityunderlyingatactiledecisioninmice AT huberdaniel flowofcorticalactivityunderlyingatactiledecisioninmice AT ophireran flowofcorticalactivityunderlyingatactiledecisioninmice AT gutniskydiego flowofcorticalactivityunderlyingatactiledecisioninmice AT fengguoping flowofcorticalactivityunderlyingatactiledecisioninmice AT svobodakarel flowofcorticalactivityunderlyingatactiledecisioninmice AT tingjonathanthomas flowofcorticalactivityunderlyingatactiledecisioninmice |