Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation
Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of mu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102407 https://orcid.org/0000-0002-8021-277X |
| _version_ | 1826211113041133568 |
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| author | Gogolla, Nadine Takesian, Anne E. Feng, Guoping Fagiolini, Michela Hensch, Takao K. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gogolla, Nadine Takesian, Anne E. Feng, Guoping Fagiolini, Michela Hensch, Takao K. |
| author_sort | Gogolla, Nadine |
| collection | MIT |
| description | Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+tf/J mouse model of idiopathic autism. The deficit reflected weakened γ-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like schizophrenia and autism. |
| first_indexed | 2024-09-23T15:01:05Z |
| format | Article |
| id | mit-1721.1/102407 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:01:05Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1024072022-10-02T00:00:06Z Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation Gogolla, Nadine Takesian, Anne E. Feng, Guoping Fagiolini, Michela Hensch, Takao K. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Feng, Guoping Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+tf/J mouse model of idiopathic autism. The deficit reflected weakened γ-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like schizophrenia and autism. 2016-05-04T22:45:29Z 2016-05-04T22:45:29Z 2014-07 Article http://purl.org/eprint/type/JournalArticle 08966273 http://hdl.handle.net/1721.1/102407 Gogolla, Nadine, Anne E. Takesian, Guoping Feng, Michela Fagiolini, and Takao K. Hensch. “Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation.” Neuron 83, no. 4 (August 2014): 894–905. https://orcid.org/0000-0002-8021-277X en_US http://dx.doi.org/10.1016/j.neuron.2014.06.033 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Gogolla, Nadine Takesian, Anne E. Feng, Guoping Fagiolini, Michela Hensch, Takao K. Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation |
| title | Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation |
| title_full | Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation |
| title_fullStr | Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation |
| title_full_unstemmed | Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation |
| title_short | Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation |
| title_sort | sensory integration in mouse insular cortex reflects gaba circuit maturation |
| url | http://hdl.handle.net/1721.1/102407 https://orcid.org/0000-0002-8021-277X |
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