Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that withi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2016
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| Online Access: | http://hdl.handle.net/1721.1/102418 |
| _version_ | 1811075451013038080 |
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| author | Kirby, E. D. Friedman, A. R. Covarrubias, D. Ying, C. Wun, W. G. Goosens, Ki Ann Sapolsky, R. M. Kaufer, D. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kirby, E. D. Friedman, A. R. Covarrubias, D. Ying, C. Wun, W. G. Goosens, Ki Ann Sapolsky, R. M. Kaufer, D. |
| author_sort | Kirby, E. D. |
| collection | MIT |
| description | Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that within the adult hippocampus, newborn neurons may contribute to support emotional memory, and that regulation of hippocampal neurogenesis is implicated in depressive disorders. How emotional information affects newborn neurons in adults is not clear. Given the role of the BLA in hippocampus-dependent emotional memory, we investigated whether hippocampal neurogenesis was sensitive to emotional stimuli from the BLA. We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus of the amygdala do not. Similarly, we show that reducing BLA activity through viral vector-mediated overexpression of an outwardly rectifying potassium channel suppresses neurogenesis. We also show that BLA lesions prevent selective activation of immature newborn neurons in response to a fear-conditioning task. These results demonstrate that BLA activity regulates adult hippocampal neurogenesis and the fear context-specific activation of newborn neurons. Together, these findings denote functional implications for proliferation and recruitment of new neurons into emotional memory circuits. |
| first_indexed | 2024-09-23T10:06:11Z |
| format | Article |
| id | mit-1721.1/102418 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:06:11Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1024182022-09-26T15:44:48Z Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons Kirby, E. D. Friedman, A. R. Covarrubias, D. Ying, C. Wun, W. G. Goosens, Ki Ann Sapolsky, R. M. Kaufer, D. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Goosens, Ki Ann Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that within the adult hippocampus, newborn neurons may contribute to support emotional memory, and that regulation of hippocampal neurogenesis is implicated in depressive disorders. How emotional information affects newborn neurons in adults is not clear. Given the role of the BLA in hippocampus-dependent emotional memory, we investigated whether hippocampal neurogenesis was sensitive to emotional stimuli from the BLA. We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus of the amygdala do not. Similarly, we show that reducing BLA activity through viral vector-mediated overexpression of an outwardly rectifying potassium channel suppresses neurogenesis. We also show that BLA lesions prevent selective activation of immature newborn neurons in response to a fear-conditioning task. These results demonstrate that BLA activity regulates adult hippocampal neurogenesis and the fear context-specific activation of newborn neurons. Together, these findings denote functional implications for proliferation and recruitment of new neurons into emotional memory circuits. Brain & Behavior Research Foundation (Young Investigator Award) National Institutes of Health (U.S.) (R01MH849662) 2016-05-09T12:39:46Z 2016-05-09T12:39:46Z 2011-06 2011-05 Article http://purl.org/eprint/type/JournalArticle 1359-4184 1476-5578 http://hdl.handle.net/1721.1/102418 Kirby, E D, A R Friedman, D Covarrubias, C Ying, W G Sun, K A Goosens, R M Sapolsky, and D Kaufer. “Basolateral Amygdala Regulation of Adult Hippocampal Neurogenesis and Fear-Related Activation of Newborn Neurons.” Mol Psychiatry 17, no. 5 (June 14, 2011): 527–536. en_US http://dx.doi.org/10.1038/mp.2011.71 Molecular Psychiatry Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Kirby, E. D. Friedman, A. R. Covarrubias, D. Ying, C. Wun, W. G. Goosens, Ki Ann Sapolsky, R. M. Kaufer, D. Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons |
| title | Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons |
| title_full | Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons |
| title_fullStr | Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons |
| title_full_unstemmed | Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons |
| title_short | Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons |
| title_sort | basolateral amygdala regulation of adult hippocampal neurogenesis and fear related activation of newborn neurons |
| url | http://hdl.handle.net/1721.1/102418 |
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