Developmental Dynamics of Rett Syndrome
Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, inclu...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | http://hdl.handle.net/1721.1/102438 https://orcid.org/0000-0001-9168-0109 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1826189130131832832 |
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| author | Banerjee, Abhishek Sur, Mriganka Feldman, Danielle Angela |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Banerjee, Abhishek Sur, Mriganka Feldman, Danielle Angela |
| author_sort | Banerjee, Abhishek |
| collection | MIT |
| description | Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss. |
| first_indexed | 2024-09-23T08:09:58Z |
| format | Article |
| id | mit-1721.1/102438 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:09:58Z |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/1024382022-09-23T11:22:04Z Developmental Dynamics of Rett Syndrome Banerjee, Abhishek Sur, Mriganka Feldman, Danielle Angela Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Feldman, Danielle Angela Banerjee, Abhishek Sur, Mriganka Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss. National Institutes of Health (U.S.) Simons Foundation 2016-05-09T16:35:36Z 2016-05-09T16:35:36Z 2016 2015-12 2016-05-08T09:30:15Z Article http://purl.org/eprint/type/JournalArticle 2090-5904 1687-5443 http://hdl.handle.net/1721.1/102438 Feldman, Danielle, Abhishek Banerjee, and Mriganka Sur. “Developmental Dynamics of Rett Syndrome.” Neural Plasticity 2016 (2016): 1–9. https://orcid.org/0000-0001-9168-0109 https://orcid.org/0000-0003-2442-5671 en http://dx.doi.org/10.1155/2016/6154080 Neural Plasticity Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2016 Danielle Feldman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Banerjee, Abhishek Sur, Mriganka Feldman, Danielle Angela Developmental Dynamics of Rett Syndrome |
| title | Developmental Dynamics of Rett Syndrome |
| title_full | Developmental Dynamics of Rett Syndrome |
| title_fullStr | Developmental Dynamics of Rett Syndrome |
| title_full_unstemmed | Developmental Dynamics of Rett Syndrome |
| title_short | Developmental Dynamics of Rett Syndrome |
| title_sort | developmental dynamics of rett syndrome |
| url | http://hdl.handle.net/1721.1/102438 https://orcid.org/0000-0001-9168-0109 https://orcid.org/0000-0003-2442-5671 |
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