Spurious group differences due to head motion in a diffusion MRI study
Diffusion-weighted MRI (DW-MRI) has become a popular imaging modality for probing the microstructural properties of white matter and comparing them between populations in vivo. However, the contrast in DW-MRI arises from the microscopic random motion of water molecules in brain tissues, which makes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102457 https://orcid.org/0000-0003-3853-7885 |
| _version_ | 1826196509596581888 |
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| author | Yendiki, Anastasia Koldewyn, Kami Kakunoori, Sita Kanwisher, Nancy Fischl, Bruce |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Yendiki, Anastasia Koldewyn, Kami Kakunoori, Sita Kanwisher, Nancy Fischl, Bruce |
| author_sort | Yendiki, Anastasia |
| collection | MIT |
| description | Diffusion-weighted MRI (DW-MRI) has become a popular imaging modality for probing the microstructural properties of white matter and comparing them between populations in vivo. However, the contrast in DW-MRI arises from the microscopic random motion of water molecules in brain tissues, which makes it particularly sensitive to macroscopic head motion. Although this has been known since the introduction of DW-MRI, most studies that use this modality for group comparisons do not report measures of head motion for each group and rely on registration-based correction methods that cannot eliminate the full effects of head motion on the DW-MRI contrast. In this work we use data from children with autism and typically developing children to investigate the effects of head motion on differences in anisotropy and diffusivity measures between groups. We show that group differences in head motion can induce group differences in DW-MRI measures, and that this is the case even when comparing groups that include control subjects only, where no anisotropy or diffusivity differences are expected. We also show that such effects can be more prominent in some white-matter pathways than others, and that they can be ameliorated by including motion as a nuisance regressor in the analyses. Our results demonstrate the importance of taking head motion into account in any population study where one group might exhibit more head motion than the other. |
| first_indexed | 2024-09-23T10:28:05Z |
| format | Article |
| id | mit-1721.1/102457 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:28:05Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1024572022-09-30T21:21:31Z Spurious group differences due to head motion in a diffusion MRI study Yendiki, Anastasia Koldewyn, Kami Kakunoori, Sita Kanwisher, Nancy Fischl, Bruce Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Koldewyn, Kami Kanwisher, Nancy Fischl, Bruce Diffusion-weighted MRI (DW-MRI) has become a popular imaging modality for probing the microstructural properties of white matter and comparing them between populations in vivo. However, the contrast in DW-MRI arises from the microscopic random motion of water molecules in brain tissues, which makes it particularly sensitive to macroscopic head motion. Although this has been known since the introduction of DW-MRI, most studies that use this modality for group comparisons do not report measures of head motion for each group and rely on registration-based correction methods that cannot eliminate the full effects of head motion on the DW-MRI contrast. In this work we use data from children with autism and typically developing children to investigate the effects of head motion on differences in anisotropy and diffusivity measures between groups. We show that group differences in head motion can induce group differences in DW-MRI measures, and that this is the case even when comparing groups that include control subjects only, where no anisotropy or diffusivity differences are expected. We also show that such effects can be more prominent in some white-matter pathways than others, and that they can be ameliorated by including motion as a nuisance regressor in the analyses. Our results demonstrate the importance of taking head motion into account in any population study where one group might exhibit more head motion than the other. Ellison Medical Foundation. Autism & Dyslexia Project National Institute for Biomedical Imaging and Bioengineering (U.S.) (Pathway to Independence Award K99/R00-EB008129) National Institute for Biomedical Imaging and Bioengineering (U.S.) (R01-EB006758) National Institutes of Health (U.S.). National Center for Research Resources (P41-RR14075) National Institutes of Health (U.S.). National Center for Research Resources (U24-RR021382) National Institute on Aging (AG022381) National Institute on Aging (5R01-AG008122-22) National Center for Complementary and Alternative Medicine (U.S.) (RC1-AT005728-01) National Institute of Neurological Disorders and Stroke (U.S.) (R01-NS052585-01) National Institute of Neurological Disorders and Stroke (U.S.) (1R21-NS072652-01) National Institute of Neurological Disorders and Stroke (U.S.) (1R01-NS070963) 2016-05-12T00:01:57Z 2016-05-12T00:01:57Z 2013-11 Article http://purl.org/eprint/type/JournalArticle 10538119 http://hdl.handle.net/1721.1/102457 Yendiki, Anastasia, Kami Koldewyn, Sita Kakunoori, Nancy Kanwisher, and Bruce Fischl. “Spurious Group Differences Due to Head Motion in a Diffusion MRI Study.” NeuroImage 88 (March 2014): 79–90. https://orcid.org/0000-0003-3853-7885 en_US http://dx.doi.org/10.1016/j.neuroimage.2013.11.027 NeuroImage Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Yendiki, Anastasia Koldewyn, Kami Kakunoori, Sita Kanwisher, Nancy Fischl, Bruce Spurious group differences due to head motion in a diffusion MRI study |
| title | Spurious group differences due to head motion in a diffusion MRI study |
| title_full | Spurious group differences due to head motion in a diffusion MRI study |
| title_fullStr | Spurious group differences due to head motion in a diffusion MRI study |
| title_full_unstemmed | Spurious group differences due to head motion in a diffusion MRI study |
| title_short | Spurious group differences due to head motion in a diffusion MRI study |
| title_sort | spurious group differences due to head motion in a diffusion mri study |
| url | http://hdl.handle.net/1721.1/102457 https://orcid.org/0000-0003-3853-7885 |
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