Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex
Inhibitory neurons are known to play a vital role in defining the window for critical period plasticity during development, and it is increasingly apparent that they continue to exert powerful control over experience-dependent cortical plasticity in adulthood. Recent in vivo imaging studies demonstr...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Sage Publications
2016
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| Online Access: | http://hdl.handle.net/1721.1/102483 https://orcid.org/0000-0002-1710-0767 |
| _version_ | 1826211132268871680 |
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| author | Chen, Jerry L. Nedivi, Elly |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Chen, Jerry L. Nedivi, Elly |
| author_sort | Chen, Jerry L. |
| collection | MIT |
| description | Inhibitory neurons are known to play a vital role in defining the window for critical period plasticity during development, and it is increasingly apparent that they continue to exert powerful control over experience-dependent cortical plasticity in adulthood. Recent in vivo imaging studies demonstrate that long-term plasticity of inhibitory circuits is manifested at an anatomical level. Changes in sensory experience drive structural remodeling in inhibitory interneurons in a cell-type and circuit-specific manner. Inhibitory synapse formation and elimination can occur with a great deal of spatial and temporal precision and are locally coordinated with excitatory synaptic changes on the same neuron. We suggest that the specificity of inhibitory synapse dynamics may serve to differentially modulate activity across the dendritic arbor, to selectively tune parts of a local circuit, or potentially discriminate between activities in distinct local circuits. We further review evidence suggesting that inhibitory circuit structural changes instruct excitatory/inhibitory balance while enabling functional reorganization to occur through Hebbian forms of plasticity. |
| first_indexed | 2024-09-23T15:01:06Z |
| format | Article |
| id | mit-1721.1/102483 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:01:06Z |
| publishDate | 2016 |
| publisher | Sage Publications |
| record_format | dspace |
| spelling | mit-1721.1/1024832022-09-29T12:06:30Z Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex Chen, Jerry L. Nedivi, Elly Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Chen, Jerry L. Nedivi, Elly Inhibitory neurons are known to play a vital role in defining the window for critical period plasticity during development, and it is increasingly apparent that they continue to exert powerful control over experience-dependent cortical plasticity in adulthood. Recent in vivo imaging studies demonstrate that long-term plasticity of inhibitory circuits is manifested at an anatomical level. Changes in sensory experience drive structural remodeling in inhibitory interneurons in a cell-type and circuit-specific manner. Inhibitory synapse formation and elimination can occur with a great deal of spatial and temporal precision and are locally coordinated with excitatory synaptic changes on the same neuron. We suggest that the specificity of inhibitory synapse dynamics may serve to differentially modulate activity across the dendritic arbor, to selectively tune parts of a local circuit, or potentially discriminate between activities in distinct local circuits. We further review evidence suggesting that inhibitory circuit structural changes instruct excitatory/inhibitory balance while enabling functional reorganization to occur through Hebbian forms of plasticity. National Institutes of Health (U.S.) (Grant RO1 EY017656) National Science Foundation (U.S.). International Research Fellowship Program (Grant 1158914) University of Zurich (Grant 54151805) 2016-05-13T18:30:13Z 2016-05-13T18:30:13Z 2013-03 Article http://purl.org/eprint/type/JournalArticle 1073-8584 1089-4098 http://hdl.handle.net/1721.1/102483 Chen, J. L., and E. Nedivi. “Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex.” The Neuroscientist 19, no. 4 (August 1, 2013): 384–93. https://orcid.org/0000-0002-1710-0767 en_US http://dx.doi.org/10.1177/1073858413479824 The Neuroscientist Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Sage Publications PMC |
| spellingShingle | Chen, Jerry L. Nedivi, Elly Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex |
| title | Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex |
| title_full | Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex |
| title_fullStr | Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex |
| title_full_unstemmed | Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex |
| title_short | Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex |
| title_sort | highly specific structural plasticity of inhibitory circuits in the adult neocortex |
| url | http://hdl.handle.net/1721.1/102483 https://orcid.org/0000-0002-1710-0767 |
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