Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35. Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. Here, we show that p25 is generated following neuronal activity u...

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Bibliographic Details
Main Authors: Seo, Jinsoo, Zhou, Ying, Rudenko, Andrii, Cho, Sukhee, Ota, Kristie, Park, Christine, Patzke, Holger, Madabhushi, Ram, Pan, Ling, Guan, Ji-Song, Delalle, Ivana, Tsai, Li-Huei, Giusti-Rodriguez, Paola, Mungenast, Alison
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102509
https://orcid.org/0000-0001-9947-9071
https://orcid.org/0000-0003-1262-0592

Internet

http://hdl.handle.net/1721.1/102509
https://orcid.org/0000-0001-9947-9071
https://orcid.org/0000-0003-1262-0592

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