The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair
Although the roles of endothelial cells in cancer have primarily been considered to be related to tumor perfusion, the emerging appreciation of “angiocrine” regulation adds stromal regulatory capabilities to the expanding list of endothelial functions in tumors. We posit that an understanding of the...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Association for Cancer Research
2016
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| Online Access: | http://hdl.handle.net/1721.1/102573 https://orcid.org/0000-0002-7832-7156 |
| _version_ | 1826207391947948032 |
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| author | Franses, Joseph W. Edelman, Elazer R. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Franses, Joseph W. Edelman, Elazer R. |
| author_sort | Franses, Joseph W. |
| collection | MIT |
| description | Although the roles of endothelial cells in cancer have primarily been considered to be related to tumor perfusion, the emerging appreciation of “angiocrine” regulation adds stromal regulatory capabilities to the expanding list of endothelial functions in tumors. We posit that an understanding of the state-dependent paracrine regulatory paradigms established in vascular disease and repair will be critical for a deep understanding of tumor biology, as endothelial cells regulate diverse processes in all vascularized tissues. Here, we outline the historical developments that led to the appreciation of the paracrine regulatory functions of endothelial cells, summarize classical views of blood vessels and stroma in cancer, and attempt to merge these ideas to include the stromal regulatory endothelial cell as a critical regulator of cancer. The notion of the endothelial cell as a biochemical regulator of cancer state in constant dynamic balance with its tumor could impact diagnosis, prognosis, and treatment of cancer. Such concepts might well explain the mixed results from antiangiogenic cancer therapeutics and how certain drugs that improve vascular health correlate with improved cancer prognosis. |
| first_indexed | 2024-09-23T13:48:35Z |
| format | Article |
| id | mit-1721.1/102573 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:48:35Z |
| publishDate | 2016 |
| publisher | American Association for Cancer Research |
| record_format | dspace |
| spelling | mit-1721.1/1025732022-10-01T17:18:59Z The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair Franses, Joseph W. Edelman, Elazer R. Harvard University--MIT Division of Health Sciences and Technology Franses, Joseph W. Edelman, Elazer R. Although the roles of endothelial cells in cancer have primarily been considered to be related to tumor perfusion, the emerging appreciation of “angiocrine” regulation adds stromal regulatory capabilities to the expanding list of endothelial functions in tumors. We posit that an understanding of the state-dependent paracrine regulatory paradigms established in vascular disease and repair will be critical for a deep understanding of tumor biology, as endothelial cells regulate diverse processes in all vascularized tissues. Here, we outline the historical developments that led to the appreciation of the paracrine regulatory functions of endothelial cells, summarize classical views of blood vessels and stroma in cancer, and attempt to merge these ideas to include the stromal regulatory endothelial cell as a critical regulator of cancer. The notion of the endothelial cell as a biochemical regulator of cancer state in constant dynamic balance with its tumor could impact diagnosis, prognosis, and treatment of cancer. Such concepts might well explain the mixed results from antiangiogenic cancer therapeutics and how certain drugs that improve vascular health correlate with improved cancer prognosis. National Institutes of Health (U.S.) (R01 GM-49039) National Institutes of Health (U.S.). Medical Scientist Training Program 2016-05-22T19:10:21Z 2016-05-22T19:10:21Z 2011-12 2011-08 Article http://purl.org/eprint/type/JournalArticle 0008-5472 1538-7445 http://hdl.handle.net/1721.1/102573 Franses, J. W., and E. R. Edelman. “The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair.” Cancer Research 71, no. 24 (December 15, 2011): 7339–44. https://orcid.org/0000-0002-7832-7156 en_US http://dx.doi.org/10.1158/0008-5472.can-11-1718 Cancer Research Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for Cancer Research PMC |
| spellingShingle | Franses, Joseph W. Edelman, Elazer R. The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair |
| title | The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair |
| title_full | The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair |
| title_fullStr | The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair |
| title_full_unstemmed | The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair |
| title_short | The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair |
| title_sort | evolution of endothelial regulatory paradigms in cancer biology and vascular repair |
| url | http://hdl.handle.net/1721.1/102573 https://orcid.org/0000-0002-7832-7156 |
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