A Method to Noninvasively Identify Cardiac Bioelectrical Sources
Background We have introduced a method to guide radiofrequency catheter ablation (RCA) procedures that estimates the location of a catheter tip used to pace the ventricles and the target site for ablation using the single equivalent moving dipole (SEMD). Objective To investigate the accuracy of t...
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2016
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| Online Access: | http://hdl.handle.net/1721.1/102578 https://orcid.org/0000-0002-4058-3832 https://orcid.org/0000-0002-5573-0137 https://orcid.org/0000-0003-3147-7912 |
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| author | Sohn, Kwanghyun Lv, Wener Lee, Kichang Galea, Anna Hirschman, Gordon Barrett, Conor Cohen, Richard J. Armoundas, Antonis A. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Sohn, Kwanghyun Lv, Wener Lee, Kichang Galea, Anna Hirschman, Gordon Barrett, Conor Cohen, Richard J. Armoundas, Antonis A. |
| author_sort | Sohn, Kwanghyun |
| collection | MIT |
| description | Background
We have introduced a method to guide radiofrequency catheter ablation (RCA) procedures that estimates the location of a catheter tip used to pace the ventricles and the target site for ablation using the single equivalent moving dipole (SEMD).
Objective
To investigate the accuracy of this method in resolving epicardial and endocardial electrical sources.
Methods
Two electrode arrays, each of nine pacing electrodes at known distances from each other, sutured on the left- and right-ventricular (LV and RV) epicardial surfaces of swine, were used to pace the heart at multiple rates, while body surface potentials from 64 sites were recorded and used to estimate the SEMD location. A similar approach was followed for pacing from catheters in the LV and RV.
Results
The overall (RV & LV) error in estimating the interelectrode distance of adjacent epicardial electrodes was 0.38 ± 0.45 cm. The overall endocardial (RV & LV) interelectrode distance error, was 0.44 ± 0.26 cm. Heart rate did not significantly affect the error of the estimated SEMD location (P > 0.05). The guiding process error became progressively smaller as the SEMD approached an epicardial target site and close to the target, the overall absolute error was ∼0.28 cm. The estimated epicardial SEMD locations preserved their topology in image space with respect to their corresponding physical location of the epicardial electrodes.
Conclusion
The proposed algorithm suggests one can efficiently and accurately resolve epicardial electrical sources without the need of an imaging modality. In addition, the error in resolving these sources is sufficient to guide RCA procedures. |
| first_indexed | 2024-09-23T11:34:23Z |
| format | Article |
| id | mit-1721.1/102578 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:34:23Z |
| publishDate | 2016 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1025782022-10-01T04:32:56Z A Method to Noninvasively Identify Cardiac Bioelectrical Sources Sohn, Kwanghyun Lv, Wener Lee, Kichang Galea, Anna Hirschman, Gordon Barrett, Conor Cohen, Richard J. Armoundas, Antonis A. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Lv, Wener Lee, Kichang Cohen, Richard J. Armoundas, Antonis A. Background We have introduced a method to guide radiofrequency catheter ablation (RCA) procedures that estimates the location of a catheter tip used to pace the ventricles and the target site for ablation using the single equivalent moving dipole (SEMD). Objective To investigate the accuracy of this method in resolving epicardial and endocardial electrical sources. Methods Two electrode arrays, each of nine pacing electrodes at known distances from each other, sutured on the left- and right-ventricular (LV and RV) epicardial surfaces of swine, were used to pace the heart at multiple rates, while body surface potentials from 64 sites were recorded and used to estimate the SEMD location. A similar approach was followed for pacing from catheters in the LV and RV. Results The overall (RV & LV) error in estimating the interelectrode distance of adjacent epicardial electrodes was 0.38 ± 0.45 cm. The overall endocardial (RV & LV) interelectrode distance error, was 0.44 ± 0.26 cm. Heart rate did not significantly affect the error of the estimated SEMD location (P > 0.05). The guiding process error became progressively smaller as the SEMD approached an epicardial target site and close to the target, the overall absolute error was ∼0.28 cm. The estimated epicardial SEMD locations preserved their topology in image space with respect to their corresponding physical location of the epicardial electrodes. Conclusion The proposed algorithm suggests one can efficiently and accurately resolve epicardial electrical sources without the need of an imaging modality. In addition, the error in resolving these sources is sufficient to guide RCA procedures. National Institutes of Health (U.S.) (Grant 1RO1HL103961) National Institutes of Health (U.S.) (Grant R44 HL079726-04) 2016-05-22T20:31:33Z 2016-05-22T20:31:33Z 2014-03 2014-01 Article http://purl.org/eprint/type/JournalArticle 01478389 1540-8159 http://hdl.handle.net/1721.1/102578 Sohn, Kwanghyun, Wener Lv, Kichang Lee, Anna Galea, Gordon Hirschman, Conor Barrett, Richard J. Cohen, and Antonis A. Armoundas. “A Method to Noninvasively Identify Cardiac Bioelectrical Sources.” Pacing and Clinical Electrophysiology 37, no. 8 (August 2014): 1038–50. https://orcid.org/0000-0002-4058-3832 https://orcid.org/0000-0002-5573-0137 https://orcid.org/0000-0003-3147-7912 en_US http://dx.doi.org/10.1111/pace.12380 Pacing and Clinical Electrophysiology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Sohn, Kwanghyun Lv, Wener Lee, Kichang Galea, Anna Hirschman, Gordon Barrett, Conor Cohen, Richard J. Armoundas, Antonis A. A Method to Noninvasively Identify Cardiac Bioelectrical Sources |
| title | A Method to Noninvasively Identify Cardiac Bioelectrical Sources |
| title_full | A Method to Noninvasively Identify Cardiac Bioelectrical Sources |
| title_fullStr | A Method to Noninvasively Identify Cardiac Bioelectrical Sources |
| title_full_unstemmed | A Method to Noninvasively Identify Cardiac Bioelectrical Sources |
| title_short | A Method to Noninvasively Identify Cardiac Bioelectrical Sources |
| title_sort | method to noninvasively identify cardiac bioelectrical sources |
| url | http://hdl.handle.net/1721.1/102578 https://orcid.org/0000-0002-4058-3832 https://orcid.org/0000-0002-5573-0137 https://orcid.org/0000-0003-3147-7912 |
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