Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm
Background We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a single equivalent moving dipole (SEMD) localization method. The method and system...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2016
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| Online Access: | http://hdl.handle.net/1721.1/102579 https://orcid.org/0000-0002-4058-3832 https://orcid.org/0000-0002-5573-0137 https://orcid.org/0000-0003-3147-7912 |
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| author | Lee, Kichang Lv, Wener Ter-Ovanesyan, Evgeny Barley, Maya E. Voysey, Graham E. Galea, Anna M. Hirschman, Gordon B. Leroy, Kristen Marini, Robert P. Barrett, Conor Armoundas, Antonis A. Cohen, Richard J. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Lee, Kichang Lv, Wener Ter-Ovanesyan, Evgeny Barley, Maya E. Voysey, Graham E. Galea, Anna M. Hirschman, Gordon B. Leroy, Kristen Marini, Robert P. Barrett, Conor Armoundas, Antonis A. Cohen, Richard J. |
| author_sort | Lee, Kichang |
| collection | MIT |
| description | Background
We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a single equivalent moving dipole (SEMD) localization method. The method and system were evaluated in both a saline tank phantom model and in vivo animal (swine) experiments.
Methods
A catheter with two platinum electrodes spaced 3 mm apart was used as the dipole source in the phantom study. A 40-Hz sinusoidal signal was applied to the electrode pair. In the animal study, four to eight electrodes were sutured onto the right ventricle. These electrodes were connected to a stimulus generator delivering 1-ms duration pacing pulses. Signals were recorded from 64 electrodes, located either on the inner surface of the saline tank or on the body surface of the pig, and then processed by the ISGA to localize the physical or bioelectrical SEMD.
Results
In the phantom studies, the guidance algorithm was used to advance a catheter tip to the location of the source dipole. The distance from the final position of the catheter tip to the position of the target dipole was 2.22 ± 0.78 mm in real space and 1.38 ± 0.78 mm in image space (computational space). The ISGA successfully tracked the locations of electrodes sutured on the ventricular myocardium and the movement of an endocardial catheter placed in the animal's right ventricle.
Conclusion
In conclusion, we successfully demonstrated the feasibility of using an SEMD inverse algorithm to guide a cardiac ablation catheter. |
| first_indexed | 2024-09-23T15:54:43Z |
| format | Article |
| id | mit-1721.1/102579 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:54:43Z |
| publishDate | 2016 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1025792022-09-29T17:00:45Z Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm Lee, Kichang Lv, Wener Ter-Ovanesyan, Evgeny Barley, Maya E. Voysey, Graham E. Galea, Anna M. Hirschman, Gordon B. Leroy, Kristen Marini, Robert P. Barrett, Conor Armoundas, Antonis A. Cohen, Richard J. Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Lee, Kichang Lv, Wener Ter-Ovanesyan, Evgeny Barley, Maya E. Marini, Robert P. Cohen, Richard J. Background We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a single equivalent moving dipole (SEMD) localization method. The method and system were evaluated in both a saline tank phantom model and in vivo animal (swine) experiments. Methods A catheter with two platinum electrodes spaced 3 mm apart was used as the dipole source in the phantom study. A 40-Hz sinusoidal signal was applied to the electrode pair. In the animal study, four to eight electrodes were sutured onto the right ventricle. These electrodes were connected to a stimulus generator delivering 1-ms duration pacing pulses. Signals were recorded from 64 electrodes, located either on the inner surface of the saline tank or on the body surface of the pig, and then processed by the ISGA to localize the physical or bioelectrical SEMD. Results In the phantom studies, the guidance algorithm was used to advance a catheter tip to the location of the source dipole. The distance from the final position of the catheter tip to the position of the target dipole was 2.22 ± 0.78 mm in real space and 1.38 ± 0.78 mm in image space (computational space). The ISGA successfully tracked the locations of electrodes sutured on the ventricular myocardium and the movement of an endocardial catheter placed in the animal's right ventricle. Conclusion In conclusion, we successfully demonstrated the feasibility of using an SEMD inverse algorithm to guide a cardiac ablation catheter. National Institutes of Health (U.S.) (Grant 4 R44H L079726-02) National Institute on Aging (Grant 1R21AG035128) National Institutes of Health (U.S.) (Grant 1RO1HL103961) Center for Integration of Medicine and Innovative Technology 2016-05-22T20:49:38Z 2016-05-22T20:49:38Z 2013-02 2012-12 Article http://purl.org/eprint/type/JournalArticle 01478389 1540-8159 http://hdl.handle.net/1721.1/102579 Lee, Kichang, Wener Lv, Evgeny Ter-Ovanesyan, Maya E. Barley, Graham E. Voysey, Anna M. Galea, Gordon B. Hirschman, et al. “Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm.” Pacing and Clinical Electrophysiology 36, no. 7 (July 2013): 811–22. https://orcid.org/0000-0002-4058-3832 https://orcid.org/0000-0002-5573-0137 https://orcid.org/0000-0003-3147-7912 en_US http://dx.doi.org/10.1111/pace.12114 Pacing and Clinical Electrophysiology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Lee, Kichang Lv, Wener Ter-Ovanesyan, Evgeny Barley, Maya E. Voysey, Graham E. Galea, Anna M. Hirschman, Gordon B. Leroy, Kristen Marini, Robert P. Barrett, Conor Armoundas, Antonis A. Cohen, Richard J. Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm |
| title | Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm |
| title_full | Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm |
| title_fullStr | Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm |
| title_full_unstemmed | Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm |
| title_short | Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm |
| title_sort | cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm |
| url | http://hdl.handle.net/1721.1/102579 https://orcid.org/0000-0002-4058-3832 https://orcid.org/0000-0002-5573-0137 https://orcid.org/0000-0003-3147-7912 |
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