Salivary mucins in host defense and disease prevention
Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical components of the gel layer that protect against...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Co-Action Publishing
2016
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| Online Access: | http://hdl.handle.net/1721.1/102597 https://orcid.org/0000-0001-8260-338X |
| _version_ | 1826205411895672832 |
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| author | Frenkel, Erica Shapiro Ribbeck, Katharina |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Frenkel, Erica Shapiro Ribbeck, Katharina |
| author_sort | Frenkel, Erica Shapiro |
| collection | MIT |
| description | Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical components of the gel layer that protect against invading pathogens. Altered mucin production has been implicated in diseases such as ulcerative colitis, asthma, and cystic fibrosis, which highlights the importance of mucins in maintaining homeostasis. Different types of mucins exist throughout the body in various locations such as the gastrointestinal tract, lungs, and female genital tract, but this review will focus on mucins in the oral cavity. Salivary mucin structure, localization within the oral cavity, and defense mechanisms will be discussed. These concepts will then be applied to present what is known about the protective function of mucins in oral diseases such as HIV/AIDS, oral candidiasis, and dental caries. |
| first_indexed | 2024-09-23T13:12:16Z |
| format | Article |
| id | mit-1721.1/102597 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:12:16Z |
| publishDate | 2016 |
| publisher | Co-Action Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1025972022-10-01T13:46:27Z Salivary mucins in host defense and disease prevention Frenkel, Erica Shapiro Ribbeck, Katharina Massachusetts Institute of Technology. Department of Biological Engineering Frenkel, Erica Shapiro Ribbeck, Katharina Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical components of the gel layer that protect against invading pathogens. Altered mucin production has been implicated in diseases such as ulcerative colitis, asthma, and cystic fibrosis, which highlights the importance of mucins in maintaining homeostasis. Different types of mucins exist throughout the body in various locations such as the gastrointestinal tract, lungs, and female genital tract, but this review will focus on mucins in the oral cavity. Salivary mucin structure, localization within the oral cavity, and defense mechanisms will be discussed. These concepts will then be applied to present what is known about the protective function of mucins in oral diseases such as HIV/AIDS, oral candidiasis, and dental caries. 2016-05-23T14:03:06Z 2016-05-23T14:03:06Z 2015-12 2015-11 Article http://purl.org/eprint/type/JournalArticle 2000-2297 http://hdl.handle.net/1721.1/102597 Frenkel, Erica Shapiro, and Katharina Ribbeck. “Salivary Mucins in Host Defense and Disease Prevention.” Journal of Oral Microbiology 7, no. 0 (December 22, 2015). https://orcid.org/0000-0001-8260-338X en_US http://dx.doi.org/10.3402/jom.v7.29759 Journal of Oral Microbiology Creative Commons Attribution http://creativecommons.org/licenses/by-nc/4.0/ application/pdf Co-Action Publishing Co-Action Publishing |
| spellingShingle | Frenkel, Erica Shapiro Ribbeck, Katharina Salivary mucins in host defense and disease prevention |
| title | Salivary mucins in host defense and disease prevention |
| title_full | Salivary mucins in host defense and disease prevention |
| title_fullStr | Salivary mucins in host defense and disease prevention |
| title_full_unstemmed | Salivary mucins in host defense and disease prevention |
| title_short | Salivary mucins in host defense and disease prevention |
| title_sort | salivary mucins in host defense and disease prevention |
| url | http://hdl.handle.net/1721.1/102597 https://orcid.org/0000-0001-8260-338X |
| work_keys_str_mv | AT frenkelericashapiro salivarymucinsinhostdefenseanddiseaseprevention AT ribbeckkatharina salivarymucinsinhostdefenseanddiseaseprevention |