Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity
The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular domin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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eLife Sciences Publications, Ltd.
2016
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| Online Access: | http://hdl.handle.net/1721.1/102620 https://orcid.org/0000-0002-3079-3772 https://orcid.org/0000-0002-7668-2867 https://orcid.org/0000-0002-3538-1056 |
| _version_ | 1826193605358780416 |
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| author | Thomazeau, Aurore Kaplan, Eitan S. Cooke, Samuel Frazer Komorowski, Robert Chubykin, Alexander A. Khibnik, Lena A. Gavornik, Jeffrey P. Bear, Mark |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Thomazeau, Aurore Kaplan, Eitan S. Cooke, Samuel Frazer Komorowski, Robert Chubykin, Alexander A. Khibnik, Lena A. Gavornik, Jeffrey P. Bear, Mark |
| author_sort | Thomazeau, Aurore |
| collection | MIT |
| description | The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity. |
| first_indexed | 2024-09-23T09:41:45Z |
| format | Article |
| id | mit-1721.1/102620 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:41:45Z |
| publishDate | 2016 |
| publisher | eLife Sciences Publications, Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/1026202022-09-30T16:15:38Z Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity Thomazeau, Aurore Kaplan, Eitan S. Cooke, Samuel Frazer Komorowski, Robert Chubykin, Alexander A. Khibnik, Lena A. Gavornik, Jeffrey P. Bear, Mark Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Kaplan, Eitan S. Cooke, Samuel Frazer Komorowski, Robert Thomazeau, Aurore Bear, Mark The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity. Howard Hughes Medical Institute National Eye Institute (5R01EYO23037) Picower Institute for Learning and Memory (Innovation Fund) National Institute of Mental Health (U.S.) (Training Grant 1T32MH074249) JPB Foundation. Junior Facutly Development Program 2016-05-23T15:51:24Z 2016-05-23T15:51:24Z 2016-03 2015-09 Article http://purl.org/eprint/type/JournalArticle 2050-084X http://hdl.handle.net/1721.1/102620 Kaplan, Eitan S, Sam F Cooke, Robert W Komorowski, Alexander A Chubykin, Aurore Thomazeau, Lena A Khibnik, Jeffrey P Gavornik, and Mark F Bear. “Contrasting Roles for Parvalbumin-Expressing Inhibitory Neurons in Two Forms of Adult Visual Cortical Plasticity.” eLife 5 (March 4, 2016). https://orcid.org/0000-0002-3079-3772 https://orcid.org/0000-0002-7668-2867 https://orcid.org/0000-0002-3538-1056 en_US http://dx.doi.org/10.7554/eLife.11450 eLife Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd. eLife Sciences Publications, Ltd. |
| spellingShingle | Thomazeau, Aurore Kaplan, Eitan S. Cooke, Samuel Frazer Komorowski, Robert Chubykin, Alexander A. Khibnik, Lena A. Gavornik, Jeffrey P. Bear, Mark Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| title | Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| title_full | Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| title_fullStr | Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| title_full_unstemmed | Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| title_short | Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| title_sort | contrasting roles for parvalbumin expressing inhibitory neurons in two forms of adult visual cortical plasticity |
| url | http://hdl.handle.net/1721.1/102620 https://orcid.org/0000-0002-3079-3772 https://orcid.org/0000-0002-7668-2867 https://orcid.org/0000-0002-3538-1056 |
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