Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

Human pluripotent stem cells (hPSCs) require precise control of post-transcriptional RNA networks to maintain proliferation and survival. Using enhanced UV crosslinking and immunoprecipitation (eCLIP), we identify RNA targets of the IMP/IGF2BP family of RNA-binding proteins in hPSCs. At the broad re...

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Bibliographic Details
Main Authors: Conway, Anne E., Van Nostrand, Eric L., Pratt, Gabriel A., Aigner, Stefan, Wilbert, Melissa L., Sundararaman, Balaji, Lambert, Nicole J., Sathe, Shashank, Liang, Tiffany Y., Essex, Anthony, Landais, Severine, Burge, Christopher B., Jones, D. Leanne, Yeo, Gene W., Freese, Peter Dale, Lambert, Nicole, Burge, Christopher B
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102627
https://orcid.org/0000-0001-7256-6845

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