Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo

In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances....

Full description

Bibliographic Details
Main Authors: El-Boustani, Sami, Sur, Mriganka
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Nature Publishing Group 2016
Online Access:http://hdl.handle.net/1721.1/102658
https://orcid.org/0000-0003-2442-5671
_version_ 1826213124466802688
author El-Boustani, Sami
Sur, Mriganka
author2 Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
author_facet Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
El-Boustani, Sami
Sur, Mriganka
author_sort El-Boustani, Sami
collection MIT
description In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances. Here, by utilizing specific visual stimuli and single optogenetic probe pulses, we show that the function of ​parvalbumin-expressing and ​somatostatin-expressing neurons in mice in vivo is governed by the overlap of response timing between these neurons and their targets. In particular, ​somatostatin-expressing neurons respond at longer latencies to small visual stimuli compared with their target neurons and provide subtractive inhibition. With large visual stimuli, however, they respond at short latencies coincident with their target cells and switch to provide divisive inhibition. These results indicate that inhibition mediated by these neurons is a dynamic property of cortical circuits rather than an immutable property of neuronal classes.
first_indexed 2024-09-23T15:43:43Z
format Article
id mit-1721.1/102658
institution Massachusetts Institute of Technology
language en_US
last_indexed 2024-09-23T15:43:43Z
publishDate 2016
publisher Nature Publishing Group
record_format dspace
spelling mit-1721.1/1026582022-10-02T03:42:23Z Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo El-Boustani, Sami Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory El-Boustani, Sami Sur, Mriganka In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances. Here, by utilizing specific visual stimuli and single optogenetic probe pulses, we show that the function of ​parvalbumin-expressing and ​somatostatin-expressing neurons in mice in vivo is governed by the overlap of response timing between these neurons and their targets. In particular, ​somatostatin-expressing neurons respond at longer latencies to small visual stimuli compared with their target neurons and provide subtractive inhibition. With large visual stimuli, however, they respond at short latencies coincident with their target cells and switch to provide divisive inhibition. These results indicate that inhibition mediated by these neurons is a dynamic property of cortical circuits rather than an immutable property of neuronal classes. Marie Curie International Fellowship (Postdoctoral Fellowship FP7-PEOPLE-2010-IOF)) National Institutes of Health (U.S.) (Grant EY007023) National Institutes of Health (U.S.) (Grant NS090473) Simons Foundation 2016-05-24T15:03:08Z 2016-05-24T15:03:08Z 2014-12 2014-09 Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/102658 El-Boustani, Sami, and Mriganka Sur. “Response-Dependent Dynamics of Cell-Specific Inhibition in Cortical Networks in Vivo.” Nature Communications 5 (December 11, 2014): 5689. https://orcid.org/0000-0003-2442-5671 en_US http://dx.doi.org/10.1038/ncomms6689 Nature Communications Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature
spellingShingle El-Boustani, Sami
Sur, Mriganka
Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
title Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
title_full Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
title_fullStr Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
title_full_unstemmed Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
title_short Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
title_sort response dependent dynamics of cell specific inhibition in cortical networks in vivo
url http://hdl.handle.net/1721.1/102658
https://orcid.org/0000-0003-2442-5671
work_keys_str_mv AT elboustanisami responsedependentdynamicsofcellspecificinhibitionincorticalnetworksinvivo
AT surmriganka responsedependentdynamicsofcellspecificinhibitionincorticalnetworksinvivo