Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances....
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| Aineistotyyppi: | Artikkeli |
| Kieli: | en_US |
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Nature Publishing Group
2016
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| Linkit: | http://hdl.handle.net/1721.1/102658 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1826213124466802688 |
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| author | El-Boustani, Sami Sur, Mriganka |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences El-Boustani, Sami Sur, Mriganka |
| author_sort | El-Boustani, Sami |
| collection | MIT |
| description | In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances. Here, by utilizing specific visual stimuli and single optogenetic probe pulses, we show that the function of parvalbumin-expressing and somatostatin-expressing neurons in mice in vivo is governed by the overlap of response timing between these neurons and their targets. In particular, somatostatin-expressing neurons respond at longer latencies to small visual stimuli compared with their target neurons and provide subtractive inhibition. With large visual stimuli, however, they respond at short latencies coincident with their target cells and switch to provide divisive inhibition. These results indicate that inhibition mediated by these neurons is a dynamic property of cortical circuits rather than an immutable property of neuronal classes. |
| first_indexed | 2024-09-23T15:43:43Z |
| format | Article |
| id | mit-1721.1/102658 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:43:43Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1026582022-10-02T03:42:23Z Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo El-Boustani, Sami Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory El-Boustani, Sami Sur, Mriganka In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances. Here, by utilizing specific visual stimuli and single optogenetic probe pulses, we show that the function of parvalbumin-expressing and somatostatin-expressing neurons in mice in vivo is governed by the overlap of response timing between these neurons and their targets. In particular, somatostatin-expressing neurons respond at longer latencies to small visual stimuli compared with their target neurons and provide subtractive inhibition. With large visual stimuli, however, they respond at short latencies coincident with their target cells and switch to provide divisive inhibition. These results indicate that inhibition mediated by these neurons is a dynamic property of cortical circuits rather than an immutable property of neuronal classes. Marie Curie International Fellowship (Postdoctoral Fellowship FP7-PEOPLE-2010-IOF)) National Institutes of Health (U.S.) (Grant EY007023) National Institutes of Health (U.S.) (Grant NS090473) Simons Foundation 2016-05-24T15:03:08Z 2016-05-24T15:03:08Z 2014-12 2014-09 Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/102658 El-Boustani, Sami, and Mriganka Sur. “Response-Dependent Dynamics of Cell-Specific Inhibition in Cortical Networks in Vivo.” Nature Communications 5 (December 11, 2014): 5689. https://orcid.org/0000-0003-2442-5671 en_US http://dx.doi.org/10.1038/ncomms6689 Nature Communications Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | El-Boustani, Sami Sur, Mriganka Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo |
| title | Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo |
| title_full | Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo |
| title_fullStr | Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo |
| title_full_unstemmed | Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo |
| title_short | Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo |
| title_sort | response dependent dynamics of cell specific inhibition in cortical networks in vivo |
| url | http://hdl.handle.net/1721.1/102658 https://orcid.org/0000-0003-2442-5671 |
| work_keys_str_mv | AT elboustanisami responsedependentdynamicsofcellspecificinhibitionincorticalnetworksinvivo AT surmriganka responsedependentdynamicsofcellspecificinhibitionincorticalnetworksinvivo |