Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex
The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102671 https://orcid.org/0000-0003-2527-3382 https://orcid.org/0000-0003-0652-5652 |
| _version_ | 1811086919350616064 |
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| author | Felix-Ortiz, Ada Celis Burgos-Robles, Anthony Noel Bhagat, Neha D. Leppla, Christopher Albert Tye, Kay |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Felix-Ortiz, Ada Celis Burgos-Robles, Anthony Noel Bhagat, Neha D. Leppla, Christopher Albert Tye, Kay |
| author_sort | Felix-Ortiz, Ada Celis |
| collection | MIT |
| description | The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either activate or inhibit BLA inputs to the mPFC during behavioral assays that assess anxiety-like behavior and social interaction. Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated plus maze and open field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects. Furthermore, activation of the BLA-mPFC pathway reduced social interaction in the resident-intruder test, whereas inhibition facilitated social interaction. These results establish a causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety-related and social behaviors. |
| first_indexed | 2024-09-23T13:36:38Z |
| format | Article |
| id | mit-1721.1/102671 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:36:38Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1026712022-09-28T15:03:04Z Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex Felix-Ortiz, Ada Celis Burgos-Robles, Anthony Noel Bhagat, Neha D. Leppla, Christopher Albert Tye, Kay Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Felix-Ortiz, Ada Celis Burgos-Robles, Anthony Noel Bhagat, Neha D. Leppla, Christopher Albert Tye, Kay The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either activate or inhibit BLA inputs to the mPFC during behavioral assays that assess anxiety-like behavior and social interaction. Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated plus maze and open field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects. Furthermore, activation of the BLA-mPFC pathway reduced social interaction in the resident-intruder test, whereas inhibition facilitated social interaction. These results establish a causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety-related and social behaviors. National Institutes of Health (U.S.) (National Research Service Award Institutional Research Training Grant 5T32GM007484-38) Brain & Behavior Research Foundation (Young Investigator Award) National Institute of Mental Health (U.S.) (Research Supplement to Promote Diversity in Health-Related Sciences) Integrative Neuronal Systems Fellowship James R. Killian Fellowship JPB Foundation Whitehall Foundation Klingenstein Foundation Alfred P. Sloan Foundation New York Stem Cell Foundation National Institutes of Health (U.S.) (R01-MH102441-01) 2016-05-25T00:15:44Z 2016-05-25T00:15:44Z 2015-07 Article http://purl.org/eprint/type/JournalArticle 03064522 1873-7544 http://hdl.handle.net/1721.1/102671 Felix-Ortiz, A.C., A. Burgos-Robles, N.D. Bhagat, C.A. Leppla, and K.M. Tye. “Bidirectional Modulation of Anxiety-Related and Social Behaviors by Amygdala Projections to the Medial Prefrontal Cortex.” Neuroscience 321 (May 2016): 197–209. https://orcid.org/0000-0003-2527-3382 https://orcid.org/0000-0003-0652-5652 en_US http://dx.doi.org/10.1016/j.neuroscience.2015.07.041 Neuroscience Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Felix-Ortiz, Ada Celis Burgos-Robles, Anthony Noel Bhagat, Neha D. Leppla, Christopher Albert Tye, Kay Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex |
| title | Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex |
| title_full | Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex |
| title_fullStr | Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex |
| title_full_unstemmed | Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex |
| title_short | Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex |
| title_sort | bidirectional modulation of anxiety related and social behaviors by amygdala projections to the medial prefrontal cortex |
| url | http://hdl.handle.net/1721.1/102671 https://orcid.org/0000-0003-2527-3382 https://orcid.org/0000-0003-0652-5652 |
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