Biasing the content of hippocampal replay during sleep
The hippocampus plays an essential role in encoding self-experienced events into memory. During sleep, neural activity in the hippocampus related to a recent experience has been observed to spontaneously reoccur, and this “replay” has been postulated to be important for memory consolidation. Task-re...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2016
|
| Online Access: | http://hdl.handle.net/1721.1/102674 https://orcid.org/0000-0001-7149-3584 |
| _version_ | 1811081240460132352 |
|---|---|
| author | Bender, Daniel A. Wilson, Matthew A. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Bender, Daniel A. Wilson, Matthew A. |
| author_sort | Bender, Daniel A. |
| collection | MIT |
| description | The hippocampus plays an essential role in encoding self-experienced events into memory. During sleep, neural activity in the hippocampus related to a recent experience has been observed to spontaneously reoccur, and this “replay” has been postulated to be important for memory consolidation. Task-related cues can enhance memory consolidation when presented during a post-training sleep session, and if memories are consolidated by hippocampal replay, a specific enhancement for this replay should also be observed. To test this, we have trained rats on an auditory-spatial association task, while recording from neuronal ensembles in the hippocampus. Here we report that during sleep, a task-related auditory cue biases reactivation events towards replaying the spatial memory associated with that cue. These results indicate that sleep replay can be manipulated by external stimulation, and provide further evidence for the role of hippocampal replay in memory consolidation. |
| first_indexed | 2024-09-23T11:43:40Z |
| format | Article |
| id | mit-1721.1/102674 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:43:40Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1026742022-09-27T21:30:23Z Biasing the content of hippocampal replay during sleep Bender, Daniel A. Wilson, Matthew A. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Bender, Daniel A. Wilson, Matthew A. The hippocampus plays an essential role in encoding self-experienced events into memory. During sleep, neural activity in the hippocampus related to a recent experience has been observed to spontaneously reoccur, and this “replay” has been postulated to be important for memory consolidation. Task-related cues can enhance memory consolidation when presented during a post-training sleep session, and if memories are consolidated by hippocampal replay, a specific enhancement for this replay should also be observed. To test this, we have trained rats on an auditory-spatial association task, while recording from neuronal ensembles in the hippocampus. Here we report that during sleep, a task-related auditory cue biases reactivation events towards replaying the spatial memory associated with that cue. These results indicate that sleep replay can be manipulated by external stimulation, and provide further evidence for the role of hippocampal replay in memory consolidation. Merck Award/Helen Hay Whitney Postdoctoral Fellowship Charles King Trust Postdoctoral Fellowship National Institutes of Health (U.S.) (NIH 1-K99-DC012321-01) National Institutes of Health (U.S.) (NIH 5R01MH061976) 2016-05-25T13:24:36Z 2016-05-25T13:24:36Z 2012-10 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/102674 Bendor, Daniel and Matthew A. Wilson. "Biasing the content of hippocampal replay during sleep." Nat Neurosci. 2012 October ; 15(10): 1439–1444. https://orcid.org/0000-0001-7149-3584 en_US http://dx.doi.org/10.1038/nn.3203 Nature Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Bender, Daniel A. Wilson, Matthew A. Biasing the content of hippocampal replay during sleep |
| title | Biasing the content of hippocampal replay during sleep |
| title_full | Biasing the content of hippocampal replay during sleep |
| title_fullStr | Biasing the content of hippocampal replay during sleep |
| title_full_unstemmed | Biasing the content of hippocampal replay during sleep |
| title_short | Biasing the content of hippocampal replay during sleep |
| title_sort | biasing the content of hippocampal replay during sleep |
| url | http://hdl.handle.net/1721.1/102674 https://orcid.org/0000-0001-7149-3584 |
| work_keys_str_mv | AT benderdaniela biasingthecontentofhippocampalreplayduringsleep AT wilsonmatthewa biasingthecontentofhippocampalreplayduringsleep |