Molecular Tools and Approaches for Optogenetics
The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases, owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlying pathogenesis. Technologies that facilitate functional dissection of distinct brain circuits are n...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102679 https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-5596-1269 |
| _version_ | 1826213519986524160 |
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| author | Mei, Yuan Zhang, Feng |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Mei, Yuan Zhang, Feng |
| author_sort | Mei, Yuan |
| collection | MIT |
| description | The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases, owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlying pathogenesis. Technologies that facilitate functional dissection of distinct brain circuits are necessary for systematic identification of disease origin and therapy. Recent developments in optogenetics technology have begun to address this challenge by enabling precise perturbation of distinct cell types based on molecular signatures, functional projections, and intracellular biochemical signaling pathways. With high temporal precision and reversible neuromodulation, optogenetics promises to improve existing disease models and advance our understanding of psychiatric conditions. In this review, we describe the current state of molecular optogenetic tools and future directions of development. |
| first_indexed | 2024-09-23T15:50:32Z |
| format | Article |
| id | mit-1721.1/102679 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:50:32Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1026792022-10-02T04:31:28Z Molecular Tools and Approaches for Optogenetics Mei, Yuan Zhang, Feng Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Mei, Yuan Zhang, Feng The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases, owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlying pathogenesis. Technologies that facilitate functional dissection of distinct brain circuits are necessary for systematic identification of disease origin and therapy. Recent developments in optogenetics technology have begun to address this challenge by enabling precise perturbation of distinct cell types based on molecular signatures, functional projections, and intracellular biochemical signaling pathways. With high temporal precision and reversible neuromodulation, optogenetics promises to improve existing disease models and advance our understanding of psychiatric conditions. In this review, we describe the current state of molecular optogenetic tools and future directions of development. National Institute of General Medical Sciences (U.S.) (Training Grant No. T32 GM007484) National Institutes of Health (U.S.) (Transformative R01) 2016-05-25T15:41:41Z 2016-05-25T15:41:41Z 2012-02 2012 Article http://purl.org/eprint/type/JournalArticle 00063223 http://hdl.handle.net/1721.1/102679 Mei, Yuan, and Feng Zhang. “Molecular Tools and Approaches for Optogenetics.” Biological Psychiatry 71, no. 12 (June 2012): 1033–1038. https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-5596-1269 en_US http://dx.doi.org/10.1016/j.biopsych.2012.02.019 Biological Psychiatry Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Mei, Yuan Zhang, Feng Molecular Tools and Approaches for Optogenetics |
| title | Molecular Tools and Approaches for Optogenetics |
| title_full | Molecular Tools and Approaches for Optogenetics |
| title_fullStr | Molecular Tools and Approaches for Optogenetics |
| title_full_unstemmed | Molecular Tools and Approaches for Optogenetics |
| title_short | Molecular Tools and Approaches for Optogenetics |
| title_sort | molecular tools and approaches for optogenetics |
| url | http://hdl.handle.net/1721.1/102679 https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-5596-1269 |
| work_keys_str_mv | AT meiyuan moleculartoolsandapproachesforoptogenetics AT zhangfeng moleculartoolsandapproachesforoptogenetics |