Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens

The reuniens nucleus in the midline thalamus projects to the medial prefrontal cortex (mPFC) and the hippocampus, and has been suggested to modulate interactions between these regions, such as spindle–ripple correlations during sleep and theta band coherence during exploratory behavior. Feedback fro...

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Detalhes bibliográficos
Principais autores: Varela, Carmen, Kumar, S., Yang, J. Y., Wilson, Matthew A.
Outros Autores: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Formato: Artigo
Idioma:en_US
Publicado em: Springer-Verlag 2016
Acesso em linha:http://hdl.handle.net/1721.1/102682
https://orcid.org/0000-0001-7149-3584
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author Varela, Carmen
Kumar, S.
Yang, J. Y.
Wilson, Matthew A.
author2 Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
author_facet Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Varela, Carmen
Kumar, S.
Yang, J. Y.
Wilson, Matthew A.
author_sort Varela, Carmen
collection MIT
description The reuniens nucleus in the midline thalamus projects to the medial prefrontal cortex (mPFC) and the hippocampus, and has been suggested to modulate interactions between these regions, such as spindle–ripple correlations during sleep and theta band coherence during exploratory behavior. Feedback from the hippocampus to the nucleus reuniens has received less attention but has the potential to influence thalamocortical networks as a function of hippocampal activation. We used the retrograde tracer cholera toxin B conjugated to two fluorophores to study thalamic projections to the dorsal and ventral hippocampus and to the prelimbic and infralimbic subregions of mPFC. We also examined the feedback connections from the hippocampus to reuniens. The goal was to evaluate the anatomical basis for direct coordination between reuniens, mPFC, and hippocampus by looking for double-labeled cells in reuniens and hippocampus. In confirmation of previous reports, the nucleus reuniens was the origin of most thalamic afferents to the dorsal hippocampus, whereas both reuniens and the lateral dorsal nucleus projected to ventral hippocampus. Feedback from hippocampus to reuniens originated primarily in the dorsal and ventral subiculum. Thalamic cells with collaterals to mPFC and hippocampus were found in reuniens, across its anteroposterior axis, and represented, on average, about 8 % of the labeled cells in reuniens. Hippocampal cells with collaterals to mPFC and reuniens were less common (~1 % of the labeled subicular cells), and located in the molecular layer of the subiculum. The results indicate that a subset of reuniens cells can directly coordinate activity in mPFC and hippocampus. Cells with collaterals in the hippocampus–reuniens–mPFC network may be important for the systems consolidation of memory traces and for theta synchronization during exploratory behavior.
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spelling mit-1721.1/1026822022-09-30T13:17:15Z Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens Varela, Carmen Kumar, S. Yang, J. Y. Wilson, Matthew A. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Varela, Carmen Kumar, S. Yang, J. Y. Wilson, Matthew A. The reuniens nucleus in the midline thalamus projects to the medial prefrontal cortex (mPFC) and the hippocampus, and has been suggested to modulate interactions between these regions, such as spindle–ripple correlations during sleep and theta band coherence during exploratory behavior. Feedback from the hippocampus to the nucleus reuniens has received less attention but has the potential to influence thalamocortical networks as a function of hippocampal activation. We used the retrograde tracer cholera toxin B conjugated to two fluorophores to study thalamic projections to the dorsal and ventral hippocampus and to the prelimbic and infralimbic subregions of mPFC. We also examined the feedback connections from the hippocampus to reuniens. The goal was to evaluate the anatomical basis for direct coordination between reuniens, mPFC, and hippocampus by looking for double-labeled cells in reuniens and hippocampus. In confirmation of previous reports, the nucleus reuniens was the origin of most thalamic afferents to the dorsal hippocampus, whereas both reuniens and the lateral dorsal nucleus projected to ventral hippocampus. Feedback from hippocampus to reuniens originated primarily in the dorsal and ventral subiculum. Thalamic cells with collaterals to mPFC and hippocampus were found in reuniens, across its anteroposterior axis, and represented, on average, about 8 % of the labeled cells in reuniens. Hippocampal cells with collaterals to mPFC and reuniens were less common (~1 % of the labeled subicular cells), and located in the molecular layer of the subiculum. The results indicate that a subset of reuniens cells can directly coordinate activity in mPFC and hippocampus. Cells with collaterals in the hippocampus–reuniens–mPFC network may be important for the systems consolidation of memory traces and for theta synchronization during exploratory behavior. National Institutes of Health (U.S.) (grant 5R01MH061976) Caja Madrid Foundation (Fellowship) 2016-05-25T18:07:38Z 2016-05-25T18:07:38Z 2016-05-25 2013-04 Article http://purl.org/eprint/type/JournalArticle 1863-2653 1863-2661 http://hdl.handle.net/1721.1/102682 Varela, C., S. Kumar, J. Y. Yang, and M. A. Wilson. “Anatomical Substrates for Direct Interactions Between Hippocampus, Medial Prefrontal Cortex, and the Thalamic Nucleus Reuniens.” Brain Struct Funct 219, no. 3 (April 10, 2013): 911–929. https://orcid.org/0000-0001-7149-3584 en_US http://dx.doi.org/10.1007/s00429-013-0543-5 Brain Structure and Function Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer-Verlag PMC
spellingShingle Varela, Carmen
Kumar, S.
Yang, J. Y.
Wilson, Matthew A.
Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
title Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
title_full Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
title_fullStr Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
title_full_unstemmed Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
title_short Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
title_sort anatomical substrates for direct interactions between hippocampus medial prefrontal cortex and the thalamic nucleus reuniens
url http://hdl.handle.net/1721.1/102682
https://orcid.org/0000-0001-7149-3584
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