Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we p...
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2016
|
| Online Access: | http://hdl.handle.net/1721.1/102792 https://orcid.org/0000-0002-5368-6996 https://orcid.org/0000-0002-3581-3162 https://orcid.org/0000-0002-9387-8212 |
| _version_ | 1826195553196703744 |
|---|---|
| author | Yen, Chun-Wan de Puig Guixe, Helena Tam, Justina Bosch, Irene Gehrke, Lee Hamad-Schifferli, Kimberly |
| author2 | Little Devices @ MIT |
| author_facet | Little Devices @ MIT Yen, Chun-Wan de Puig Guixe, Helena Tam, Justina Bosch, Irene Gehrke, Lee Hamad-Schifferli, Kimberly |
| author_sort | Yen, Chun-Wan |
| collection | MIT |
| description | Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we present a platform for multiplexed pathogen detection using multi-colored silver nanoplates. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing. |
| first_indexed | 2024-09-23T10:14:32Z |
| format | Article |
| id | mit-1721.1/102792 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:14:32Z |
| publishDate | 2016 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | mit-1721.1/1027922022-09-30T19:53:26Z Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses Yen, Chun-Wan de Puig Guixe, Helena Tam, Justina Bosch, Irene Gehrke, Lee Hamad-Schifferli, Kimberly Little Devices @ MIT MIT-SUTD Collaboration Office Lincoln Laboratory Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science Yen, Chun-Wan de Puig Guixe, Helena Tam, Justina Bosch, Irene Hamad, Kimberly S. Gehrke, Lee Gomez-Marquez, Jose Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we present a platform for multiplexed pathogen detection using multi-colored silver nanoplates. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing. National Institutes of Health (U.S.) (NIH NIAID (AI100190)) SUTD-MIT International Design Centre (IDC) 2016-06-01T20:22:04Z 2016-06-01T20:22:04Z 2015-02 2015-01 Article http://purl.org/eprint/type/JournalArticle 1473-0197 1473-0189 http://hdl.handle.net/1721.1/102792 Yen, Chun-Wan, Helena de Puig, Justina O. Tam, Jose Gomez-Marquez, Irene Bosch, Kimberly Hamad-Schifferli and Lee Gehrke. "Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses." Lab Chip, 2015,15, 1638-1641. https://orcid.org/0000-0002-5368-6996 https://orcid.org/0000-0002-3581-3162 https://orcid.org/0000-0002-9387-8212 en_US http://dx.doi.org/10.1039/c5lc00055f Lab on a Chip Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry PMC |
| spellingShingle | Yen, Chun-Wan de Puig Guixe, Helena Tam, Justina Bosch, Irene Gehrke, Lee Hamad-Schifferli, Kimberly Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses |
| title | Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses |
| title_full | Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses |
| title_fullStr | Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses |
| title_full_unstemmed | Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses |
| title_short | Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses |
| title_sort | multicolored silver nanoparticles for multiplexed disease diagnostics distinguishing dengue yellow fever and ebola viruses |
| url | http://hdl.handle.net/1721.1/102792 https://orcid.org/0000-0002-5368-6996 https://orcid.org/0000-0002-3581-3162 https://orcid.org/0000-0002-9387-8212 |
| work_keys_str_mv | AT yenchunwan multicoloredsilvernanoparticlesformultiplexeddiseasediagnosticsdistinguishingdengueyellowfeverandebolaviruses AT depuigguixehelena multicoloredsilvernanoparticlesformultiplexeddiseasediagnosticsdistinguishingdengueyellowfeverandebolaviruses AT tamjustina multicoloredsilvernanoparticlesformultiplexeddiseasediagnosticsdistinguishingdengueyellowfeverandebolaviruses AT boschirene multicoloredsilvernanoparticlesformultiplexeddiseasediagnosticsdistinguishingdengueyellowfeverandebolaviruses AT gehrkelee multicoloredsilvernanoparticlesformultiplexeddiseasediagnosticsdistinguishingdengueyellowfeverandebolaviruses AT hamadschifferlikimberly multicoloredsilvernanoparticlesformultiplexeddiseasediagnosticsdistinguishingdengueyellowfeverandebolaviruses |