Diverse intracellular pathogens activate type III interferon expression from peroxisomes
Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon–independent responses are undefined....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2016
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| Online Access: | http://hdl.handle.net/1721.1/102793 https://orcid.org/0000-0002-9387-8212 |
| _version_ | 1811076559034908672 |
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| author | Odendall, Charlotte Dixit, Evelyn Stavru, Fabrizia Bierne, Helene Franz, Kate M Boulant, Steeve Gehrke, Lee Cossart, Pascale Kagan, Jonathan C Durbin, Ann F |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Odendall, Charlotte Dixit, Evelyn Stavru, Fabrizia Bierne, Helene Franz, Kate M Boulant, Steeve Gehrke, Lee Cossart, Pascale Kagan, Jonathan C Durbin, Ann F |
| author_sort | Odendall, Charlotte |
| collection | MIT |
| description | Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon–independent responses are undefined. We found that RIG-I like receptors (RLRs) induce type III interferon expression in a variety of human cell types, and identified factors that differentially regulate expression of type I and type III interferons. We identified peroxisomes as a primary site of initiation of type III interferon expression, and revealed that the process of intestinal epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III interferon responses in human cells. These findings highlight the importance of different intracellular organelles in specific innate immune responses. |
| first_indexed | 2024-09-23T10:24:08Z |
| format | Article |
| id | mit-1721.1/102793 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:24:08Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1027932022-09-26T17:37:17Z Diverse intracellular pathogens activate type III interferon expression from peroxisomes Odendall, Charlotte Dixit, Evelyn Stavru, Fabrizia Bierne, Helene Franz, Kate M Boulant, Steeve Gehrke, Lee Cossart, Pascale Kagan, Jonathan C Durbin, Ann F Massachusetts Institute of Technology. Institute for Medical Engineering & Science Durbin, Ann Fiegen Gehrke, Lee Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon–independent responses are undefined. We found that RIG-I like receptors (RLRs) induce type III interferon expression in a variety of human cell types, and identified factors that differentially regulate expression of type I and type III interferons. We identified peroxisomes as a primary site of initiation of type III interferon expression, and revealed that the process of intestinal epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III interferon responses in human cells. These findings highlight the importance of different intracellular organelles in specific innate immune responses. National Institutes of Health (U.S.) (NIH grant AI093589) National Institutes of Health (U.S.) (NIH grant AI072955) National Institutes of Health (U.S.) (NIH grant P30 DK34854) National Institutes of Health (U.S.) (NIH grant CA159132) 2016-06-01T20:33:11Z 2016-06-01T20:33:11Z 2014-08 2014-03 Article http://purl.org/eprint/type/JournalArticle 1529-2908 1529-2916 http://hdl.handle.net/1721.1/102793 Odendall, Charlotte, Evelyn Dixit, Fabrizia Stavru, Helene Bierne, Kate M. Franz, Ann Fiegen Durbin, Steeve Boulant, Lee Gehrke, Pascale Cossart, and Jonathan C. Kagan. “Diverse Intracellular Pathogens Activate Type III Interferon Expression from Peroxisomes.” Nat Immunol 15, no. 8 (June 22, 2014): 717–726. https://orcid.org/0000-0002-9387-8212 en_US http://dx.doi.org/10.1038/ni.2915 Nature Immunology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Odendall, Charlotte Dixit, Evelyn Stavru, Fabrizia Bierne, Helene Franz, Kate M Boulant, Steeve Gehrke, Lee Cossart, Pascale Kagan, Jonathan C Durbin, Ann F Diverse intracellular pathogens activate type III interferon expression from peroxisomes |
| title | Diverse intracellular pathogens activate type III interferon expression from peroxisomes |
| title_full | Diverse intracellular pathogens activate type III interferon expression from peroxisomes |
| title_fullStr | Diverse intracellular pathogens activate type III interferon expression from peroxisomes |
| title_full_unstemmed | Diverse intracellular pathogens activate type III interferon expression from peroxisomes |
| title_short | Diverse intracellular pathogens activate type III interferon expression from peroxisomes |
| title_sort | diverse intracellular pathogens activate type iii interferon expression from peroxisomes |
| url | http://hdl.handle.net/1721.1/102793 https://orcid.org/0000-0002-9387-8212 |
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