Increased incidence of diuretic use in critically ill obese patients
available in PMC 2015 October 29
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/102866 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
| _version_ | 1826189926068125696 |
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| author | de Louw, Emma J. Sun, Pepijn O. Lee, Joon Feng, Mengling Mark, Roger G. Celi, Leo Anthony G. Mukamal, Kenneth J. Danziger, John |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science de Louw, Emma J. Sun, Pepijn O. Lee, Joon Feng, Mengling Mark, Roger G. Celi, Leo Anthony G. Mukamal, Kenneth J. Danziger, John |
| author_sort | de Louw, Emma J. |
| collection | MIT |
| description | available in PMC 2015 October 29 |
| first_indexed | 2024-09-23T08:30:14Z |
| format | Article |
| id | mit-1721.1/102866 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:30:14Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1028662024-03-20T20:08:01Z Increased incidence of diuretic use in critically ill obese patients de Louw, Emma J. Sun, Pepijn O. Lee, Joon Feng, Mengling Mark, Roger G. Celi, Leo Anthony G. Mukamal, Kenneth J. Danziger, John Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Institute for Medical Engineering & Science Lee, Joon Feng, Mengling Mark, Roger G. Celi, Leo Anthony G. available in PMC 2015 October 29 Objective—Sodium retention occurs commonly in cardiac and liver disease, requiring the administration of diuretics to restore fluid balance. Whether obesity is associated with sodium retention has not been fully evaluated. Methods—In a large single-center cohort of critically ill patients, we evaluated whether admission body mass index was associated with the administration of either oral or intravenous diuretics during the intensive care unit (ICU) stay. Main results—Of 7724 critically ill patients, 3946 (51.1%) were prescribed diuretics during the ICU stay. Overweight, class I obesity, and class II/III obesity were associated with a 1.35 (95% confidence interval [CI], 1.20–1.53; P < .001), 1.56 (95% CI, 1.35–1.80; P < .001), and 1.91 (95% CI, 1.61–2.26; P < .001) adjusted risk of receiving diuretics within the ICU, respectively. In adjusted analysis, a 5-kg/m2 increment of body mass index was associated with a 1.19 (95% CI, 1.14–1.23; P < .001) increased adjusted risk of within-ICU diuretics. Among those patients receiving loop diuretics, obese patients received significantly larger daily diuretic doses. Conclusion—Critically ill obese patients are more likely to receive diuretics during their stay in the ICU and to receive higher dosages of diuretics. Our data suggest that obesity is an independent risk factor for sodium retention. National Institutes of Health (U.S.) (NIH grant R01 EB001659) National Institute for Biomedical Imaging and Bioengineering (U.S.) (NIBIB grant 2R01 EB001659) 2016-06-02T20:19:29Z 2016-06-02T20:19:29Z 2015-06 Article http://purl.org/eprint/type/JournalArticle 08839441 http://hdl.handle.net/1721.1/102866 De Louw, Emma J., Pepijn O. Sun, Joon Lee, Mengling Feng, Roger G. Mark, Leo Anthony Celi, Kenneth J. Mukamal, and John Danziger. “Increased Incidence of Diuretic Use in Critically Ill Obese Patients.” Journal of Critical Care 30, no. 3 (June 2015): 619–623. https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 en_US http://dx.doi.org/10.1016/j.jcrc.2015.01.023 Journal of Critical Care Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | de Louw, Emma J. Sun, Pepijn O. Lee, Joon Feng, Mengling Mark, Roger G. Celi, Leo Anthony G. Mukamal, Kenneth J. Danziger, John Increased incidence of diuretic use in critically ill obese patients |
| title | Increased incidence of diuretic use in critically ill obese patients |
| title_full | Increased incidence of diuretic use in critically ill obese patients |
| title_fullStr | Increased incidence of diuretic use in critically ill obese patients |
| title_full_unstemmed | Increased incidence of diuretic use in critically ill obese patients |
| title_short | Increased incidence of diuretic use in critically ill obese patients |
| title_sort | increased incidence of diuretic use in critically ill obese patients |
| url | http://hdl.handle.net/1721.1/102866 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
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