Resolving the neural circuits of anxiety
Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2016
|
| Online Access: | http://hdl.handle.net/1721.1/102969 https://orcid.org/0000-0002-4191-6926 |
| _version_ | 1826201198377566208 |
|---|---|
| author | Calhoon, Gwendolyn G. Tye, Kay |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Calhoon, Gwendolyn G. Tye, Kay |
| author_sort | Calhoon, Gwendolyn G. |
| collection | MIT |
| description | Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety and thereby provides a roadmap for future therapeutic development. |
| first_indexed | 2024-09-23T11:47:45Z |
| format | Article |
| id | mit-1721.1/102969 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:47:45Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1029692022-09-27T21:59:01Z Resolving the neural circuits of anxiety Calhoon, Gwendolyn G. Tye, Kay Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Tye, Kay Calhoon, Gwendolyn G. Tye, Kay Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety and thereby provides a roadmap for future therapeutic development. National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (NIH Director’s New Innovator Award DP2-DK-102256-01) National Institute of Mental Health (U.S.) (NIH) R01-MH102441-01) JPB Foundation 2016-06-06T14:37:42Z 2016-06-06T14:37:42Z 2015-10 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/102969 Calhoon, Gwendolyn G. and Kay M. Tye. "Resolving the neural circuits of anxiety." Nature Neuroscience 18:10 (October 2015), pp. 1394-1404. https://orcid.org/0000-0002-4191-6926 en_US http://dx.doi.org/10.1038/nn.4101 Nature Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group Prof. Tye via Courtney Crummett |
| spellingShingle | Calhoon, Gwendolyn G. Tye, Kay Resolving the neural circuits of anxiety |
| title | Resolving the neural circuits of anxiety |
| title_full | Resolving the neural circuits of anxiety |
| title_fullStr | Resolving the neural circuits of anxiety |
| title_full_unstemmed | Resolving the neural circuits of anxiety |
| title_short | Resolving the neural circuits of anxiety |
| title_sort | resolving the neural circuits of anxiety |
| url | http://hdl.handle.net/1721.1/102969 https://orcid.org/0000-0002-4191-6926 |
| work_keys_str_mv | AT calhoongwendolyng resolvingtheneuralcircuitsofanxiety AT tyekay resolvingtheneuralcircuitsofanxiety |