Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy
Skeletal muscle tissue engineering is one of the important ways for regenerating functionally defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a progressive disease due to mutations of the dystrophin gene leading to progressive myofiber degeneration with severe sympt...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer US
2016
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| Online Access: | http://hdl.handle.net/1721.1/103523 |
| _version_ | 1826191331686350848 |
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| author | Ostrovidov, Serge Shi, Xuetao Sadeghian, Ramin Banan Salehi, Sahar Fujie, Toshinori Bae, Hojae Ramalingam, Murugan Khademhosseini, Ali |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Ostrovidov, Serge Shi, Xuetao Sadeghian, Ramin Banan Salehi, Sahar Fujie, Toshinori Bae, Hojae Ramalingam, Murugan Khademhosseini, Ali |
| author_sort | Ostrovidov, Serge |
| collection | MIT |
| description | Skeletal muscle tissue engineering is one of the important ways for regenerating functionally defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a progressive disease due to mutations of the dystrophin gene leading to progressive myofiber degeneration with severe symptoms. Although current therapies in muscular dystrophy are still very challenging, important progress has been made in materials science and in cellular technologies with the use of stem cells. It is therefore useful to review these advances and the results obtained in a clinical point of view. This article focuses on the differentiation of stem cells into myoblasts, and their application in muscular dystrophy. After an overview of the different stem cells that can be induced to differentiate into the myogenic lineage, we introduce scaffolding materials used for muscular tissue engineering. We then described some widely used methods to differentiate different types of stem cell into myoblasts. We highlight recent insights obtained in therapies for muscular dystrophy. Finally, we conclude with a discussion on stem cell technology. We discussed in parallel the benefits brought by the evolution of the materials and by the expansion of cell sources which can differentiate into myoblasts. We also discussed on future challenges for clinical applications and how to accelerate the translation from the research to the clinic in the frame of DMD. |
| first_indexed | 2024-09-23T08:54:15Z |
| format | Article |
| id | mit-1721.1/103523 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:54:15Z |
| publishDate | 2016 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1035232022-09-30T12:05:09Z Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy Ostrovidov, Serge Shi, Xuetao Sadeghian, Ramin Banan Salehi, Sahar Fujie, Toshinori Bae, Hojae Ramalingam, Murugan Khademhosseini, Ali Harvard University--MIT Division of Health Sciences and Technology Khademhosseini, Ali Skeletal muscle tissue engineering is one of the important ways for regenerating functionally defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a progressive disease due to mutations of the dystrophin gene leading to progressive myofiber degeneration with severe symptoms. Although current therapies in muscular dystrophy are still very challenging, important progress has been made in materials science and in cellular technologies with the use of stem cells. It is therefore useful to review these advances and the results obtained in a clinical point of view. This article focuses on the differentiation of stem cells into myoblasts, and their application in muscular dystrophy. After an overview of the different stem cells that can be induced to differentiate into the myogenic lineage, we introduce scaffolding materials used for muscular tissue engineering. We then described some widely used methods to differentiate different types of stem cell into myoblasts. We highlight recent insights obtained in therapies for muscular dystrophy. Finally, we conclude with a discussion on stem cell technology. We discussed in parallel the benefits brought by the evolution of the materials and by the expansion of cell sources which can differentiate into myoblasts. We also discussed on future challenges for clinical applications and how to accelerate the translation from the research to the clinic in the frame of DMD. World Premier International Research Center Initiative (WPI) 2016-07-01T22:50:17Z 2016-07-01T22:50:17Z 2015-09 2016-05-23T12:17:48Z Article http://purl.org/eprint/type/JournalArticle 1550-8943 1558-6804 http://hdl.handle.net/1721.1/103523 Ostrovidov, Serge, Xuetao Shi, Ramin Banan Sadeghian, Sahar Salehi, Toshinori Fujie, Hojae Bae, Murugan Ramalingam, and Ali Khademhosseini. “Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy.” Stem Cell Reviews and Reports (September 2, 2015). en http://dx.doi.org/10.1007/s12015-015-9618-4 Stem Cell Reviews and Reports Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer Science+Business Media New York application/pdf Springer US Springer US |
| spellingShingle | Ostrovidov, Serge Shi, Xuetao Sadeghian, Ramin Banan Salehi, Sahar Fujie, Toshinori Bae, Hojae Ramalingam, Murugan Khademhosseini, Ali Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy |
| title | Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy |
| title_full | Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy |
| title_fullStr | Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy |
| title_full_unstemmed | Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy |
| title_short | Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy |
| title_sort | stem cell differentiation toward the myogenic lineage for muscle tissue regeneration a focus on muscular dystrophy |
| url | http://hdl.handle.net/1721.1/103523 |
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