The matrix reloaded: the evolution of regenerative hydrogels
Cell-laden hydrogels can regenerate lost, damaged or malfunctioning tissues. Clinical success of such hydrogels is strongly dependent on the ability to tune their chemical, physico-mechanical, and biological properties to a specific application. In particular, mimicking the intricate arrangement of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/103553 |
| _version_ | 1811097789222879232 |
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| author | Jabbari, Esmaiel Leijten, Jeroen Xu, Qiaobing Khademhosseini, Alireza |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Jabbari, Esmaiel Leijten, Jeroen Xu, Qiaobing Khademhosseini, Alireza |
| author_sort | Jabbari, Esmaiel |
| collection | MIT |
| description | Cell-laden hydrogels can regenerate lost, damaged or malfunctioning tissues. Clinical success of such hydrogels is strongly dependent on the ability to tune their chemical, physico-mechanical, and biological properties to a specific application. In particular, mimicking the intricate arrangement of cell-interactive ligands of natural tissues is crucial to proper tissue function. Natural extracellular matrix elements represent a unique source for generating such interactions. A plethora of extracellular matrix-based approaches have been explored to augment the regenerative potential of hydrogels. These efforts include the development of matrix-like hydrogels, hydrogels containing matrix-like molecules, hydrogels containing decellularized matrix, hydrogels derived from decellularized matrix, and decellularized tissues as reimplantable matrix hydrogels. Here we review the evolution, strengths and weaknesses of these developments from the perspective of creating tissue regenerating hydrogels. |
| first_indexed | 2024-09-23T17:04:58Z |
| format | Article |
| id | mit-1721.1/103553 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:04:58Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1035532022-10-03T10:17:38Z The matrix reloaded: the evolution of regenerative hydrogels Jabbari, Esmaiel Leijten, Jeroen Xu, Qiaobing Khademhosseini, Alireza Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Leijten, Jeroen Khademhosseini, Alireza Cell-laden hydrogels can regenerate lost, damaged or malfunctioning tissues. Clinical success of such hydrogels is strongly dependent on the ability to tune their chemical, physico-mechanical, and biological properties to a specific application. In particular, mimicking the intricate arrangement of cell-interactive ligands of natural tissues is crucial to proper tissue function. Natural extracellular matrix elements represent a unique source for generating such interactions. A plethora of extracellular matrix-based approaches have been explored to augment the regenerative potential of hydrogels. These efforts include the development of matrix-like hydrogels, hydrogels containing matrix-like molecules, hydrogels containing decellularized matrix, hydrogels derived from decellularized matrix, and decellularized tissues as reimplantable matrix hydrogels. Here we review the evolution, strengths and weaknesses of these developments from the perspective of creating tissue regenerating hydrogels. National Science Foundation (U.S.) (NSF Grant DMR1049381) National Science Foundation (U.S.) (NSF Grant Grant Nos. IIP- 1357109) National Science Foundation (U.S.) (NSF Grant CBET1403545) National Institutes of Health (U.S.) (NIH Grant No. AR063745) Pew Charitable Trusts National Institutes of Health (U.S.) (NIH Grant No. 1R03EB017402-01) Fonds voor Wetenschappelijk Onderzoek--Vlaanderen (FWO) (Grant No. 1208715N) National Science Foundation (U.S.) (Grant No. 1208715N) National Science Foundation (U.S.) (NSF Grant IMMODGEL (602694)) National Institutes of Health (U.S.) (EB012597) National Institutes of Health (U.S.) (NIH grant AR057837) National Institutes of Health (U.S.) (NIH grant DE021468) National Institutes of Health (U.S.) (NIH grant HL099073) National Institutes of Health (U.S.) (NIH grant AI105024) National Institutes of Health (U.S.) (NIH Grant No. AR063745) 2016-07-08T17:54:33Z 2016-07-08T17:54:33Z 2016-05 Article http://purl.org/eprint/type/JournalArticle 13697021 http://hdl.handle.net/1721.1/103553 Jabbari, Esmaiel, Jeroen Leijten, Qiaobing Xu, and Ali Khademhosseini. “The Matrix Reloaded: The Evolution of Regenerative Hydrogels.” Materials Today 19, no. 4 (May 2016): 190–196. en_US http://dx.doi.org/10.1016/j.mattod.2015.10.005 Materials Today Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Jabbari, Esmaiel Leijten, Jeroen Xu, Qiaobing Khademhosseini, Alireza The matrix reloaded: the evolution of regenerative hydrogels |
| title | The matrix reloaded: the evolution of regenerative hydrogels |
| title_full | The matrix reloaded: the evolution of regenerative hydrogels |
| title_fullStr | The matrix reloaded: the evolution of regenerative hydrogels |
| title_full_unstemmed | The matrix reloaded: the evolution of regenerative hydrogels |
| title_short | The matrix reloaded: the evolution of regenerative hydrogels |
| title_sort | matrix reloaded the evolution of regenerative hydrogels |
| url | http://hdl.handle.net/1721.1/103553 |
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