Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation
Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in LTTMs is greater than in aqueous solution at extr...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer US
2016
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| Online Access: | http://hdl.handle.net/1721.1/103634 https://orcid.org/0000-0003-3830-714X |
| _version_ | 1811096019129073664 |
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| author | Su, Erzheng Klibanov, Alexander M. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Su, Erzheng Klibanov, Alexander M. |
| author_sort | Su, Erzheng |
| collection | MIT |
| description | Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in LTTMs is greater than in aqueous solution at extreme pHs. Separately, the water-sensitive drug aspirin is found to form concentrated transparent LTTMs, where it is some 10-fold more stable against cleavage than in water. |
| first_indexed | 2024-09-23T16:37:02Z |
| format | Article |
| id | mit-1721.1/103634 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:37:02Z |
| publishDate | 2016 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1036342022-09-29T20:23:06Z Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation Su, Erzheng Klibanov, Alexander M. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemistry Klibanov, Alexander M. Su, Erzheng Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in LTTMs is greater than in aqueous solution at extreme pHs. Separately, the water-sensitive drug aspirin is found to form concentrated transparent LTTMs, where it is some 10-fold more stable against cleavage than in water. 2016-07-15T22:11:23Z 2016-07-15T22:11:23Z 2015-08 2015-05 2016-05-23T12:17:44Z Article http://purl.org/eprint/type/JournalArticle 0273-2289 1559-0291 http://hdl.handle.net/1721.1/103634 Su, Erzheng, and Alexander M. Klibanov. “Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation.” Applied Biochemistry and Biotechnology 177, no. 3 (August 4, 2015): 753–758. https://orcid.org/0000-0003-3830-714X en http://dx.doi.org/10.1007/s12010-015-1777-x Applied Biochemistry and Biotechnology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Springer Science+Business Media New York application/pdf Springer US Springer US |
| spellingShingle | Su, Erzheng Klibanov, Alexander M. Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation |
| title | Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation |
| title_full | Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation |
| title_fullStr | Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation |
| title_full_unstemmed | Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation |
| title_short | Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation |
| title_sort | low transition temperature mixtures lttms for dissolving proteins and for drug formulation |
| url | http://hdl.handle.net/1721.1/103634 https://orcid.org/0000-0003-3830-714X |
| work_keys_str_mv | AT suerzheng lowtransitiontemperaturemixtureslttmsfordissolvingproteinsandfordrugformulation AT klibanovalexanderm lowtransitiontemperaturemixtureslttmsfordissolvingproteinsandfordrugformulation |