Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb
Circuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Further...
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| 语言: | en_US |
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Nature Publishing Group
2016
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| 在线阅读: | http://hdl.handle.net/1721.1/103754 https://orcid.org/0000-0002-0419-3351 |
| _version_ | 1826214762837442560 |
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| author | Fukunaga, Izumi Herb, Jan T. Kollo, Mihaly Boyden, Edward Stuart Schaefer, Andreas T. |
| author2 | Massachusetts Institute of Technology. Synthetic Neurobiology Group |
| author_facet | Massachusetts Institute of Technology. Synthetic Neurobiology Group Fukunaga, Izumi Herb, Jan T. Kollo, Mihaly Boyden, Edward Stuart Schaefer, Andreas T. |
| author_sort | Fukunaga, Izumi |
| collection | MIT |
| description | Circuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Furthermore, inhibitory interneurons that are generally implicated in rhythm generation are segregated into distinct layers, neatly separating local and global motifs. We combined intracellular recordings in vivo with circuit-specific optogenetic interference to examine the contribution of inhibition to rhythmic activity in the mouse olfactory bulb. We found that the two inhibitory circuits controlled rhythms on distinct timescales: local, glomerular networks coordinated theta activity, regulating baseline and odor-evoked inhibition, whereas granule cells orchestrated gamma synchrony and spike timing. Notably, granule cells did not contribute to baseline rhythms or sniff-coupled odor-evoked inhibition. Thus, activities on theta and gamma timescales are controlled by separate, dissociable inhibitory networks in the olfactory bulb. |
| first_indexed | 2024-09-23T16:10:45Z |
| format | Article |
| id | mit-1721.1/103754 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:10:45Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1037542022-10-02T06:53:47Z Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb Fukunaga, Izumi Herb, Jan T. Kollo, Mihaly Boyden, Edward Stuart Schaefer, Andreas T. Massachusetts Institute of Technology. Synthetic Neurobiology Group Massachusetts Institute of Technology. Media Laboratory Boyden, Edward Stuart Circuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Furthermore, inhibitory interneurons that are generally implicated in rhythm generation are segregated into distinct layers, neatly separating local and global motifs. We combined intracellular recordings in vivo with circuit-specific optogenetic interference to examine the contribution of inhibition to rhythmic activity in the mouse olfactory bulb. We found that the two inhibitory circuits controlled rhythms on distinct timescales: local, glomerular networks coordinated theta activity, regulating baseline and odor-evoked inhibition, whereas granule cells orchestrated gamma synchrony and spike timing. Notably, granule cells did not contribute to baseline rhythms or sniff-coupled odor-evoked inhibition. Thus, activities on theta and gamma timescales are controlled by separate, dissociable inhibitory networks in the olfactory bulb. Deutsche Forschungsgemeinschaft (DFG-SPP1392) Max Planck Society for the Advancement of Science Alexander von Humboldt-Stiftung Germany. Federal Ministry of Education and Research (US-German collaboration computational neuroscience) Medical Research Council (Great Britain) (MC_UP_1202/5) University of Tubingen (ExcellenzCluster Cell Networks) 2016-07-19T14:40:13Z 2016-07-19T14:40:13Z 2014-07 2014-02 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/103754 Fukunaga, Izumi, Jan T Herb, Mihaly Kollo, Edward S Boyden, and Andreas T Schaefer. “Independent Control of Gamma and Theta Activity by Distinct Interneuron Networks in the Olfactory Bulb.” Nat Neurosci 17, no. 9 (July 6, 2014): 1208–1216. https://orcid.org/0000-0002-0419-3351 en_US http://dx.doi.org/10.1038/nn.3760 Nature Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Fukunaga, Izumi Herb, Jan T. Kollo, Mihaly Boyden, Edward Stuart Schaefer, Andreas T. Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| title | Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| title_full | Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| title_fullStr | Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| title_full_unstemmed | Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| title_short | Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| title_sort | independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb |
| url | http://hdl.handle.net/1721.1/103754 https://orcid.org/0000-0002-0419-3351 |
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