SMC complexes link gene expression and genome architecture
The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expressi...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/103905 https://orcid.org/0000-0001-8855-8647 |
| _version_ | 1826194874004668416 |
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| author | Dowen, Jill M. Young, Richard A. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Dowen, Jill M. Young, Richard A. |
| author_sort | Dowen, Jill M. |
| collection | MIT |
| description | The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations. |
| first_indexed | 2024-09-23T10:03:31Z |
| format | Article |
| id | mit-1721.1/103905 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:03:31Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1039052022-09-26T15:27:10Z SMC complexes link gene expression and genome architecture Dowen, Jill M. Young, Richard A. Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Young, Richard A. The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations. National Institutes of Health (U.S.) (Ruth L Kirschstein National Research Service Award (CA168263-01A1)) National Cancer Institute (U.S.) National Institutes of Health (U.S.) (NIH grant HG002668) 2016-08-11T19:51:40Z 2016-08-11T19:51:40Z 2014-05 Article http://purl.org/eprint/type/JournalArticle 0959437X http://hdl.handle.net/1721.1/103905 Dowen, Jill M., and Richard A. Young. “SMC Complexes Link Gene Expression and Genome Architecture.” Current Opinion in Genetics & Development 25 (April 2014): 131–137. https://orcid.org/0000-0001-8855-8647 en_US http://dx.doi.org/10.1016/j.gde.2013.11.009 Current Opinion in Genetics & Development Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Dowen, Jill M. Young, Richard A. SMC complexes link gene expression and genome architecture |
| title | SMC complexes link gene expression and genome architecture |
| title_full | SMC complexes link gene expression and genome architecture |
| title_fullStr | SMC complexes link gene expression and genome architecture |
| title_full_unstemmed | SMC complexes link gene expression and genome architecture |
| title_short | SMC complexes link gene expression and genome architecture |
| title_sort | smc complexes link gene expression and genome architecture |
| url | http://hdl.handle.net/1721.1/103905 https://orcid.org/0000-0001-8855-8647 |
| work_keys_str_mv | AT dowenjillm smccomplexeslinkgeneexpressionandgenomearchitecture AT youngricharda smccomplexeslinkgeneexpressionandgenomearchitecture |