Transcriptional Regulation and Its Misregulation in Disease
Available in PMC 2014 March 14.
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/103908 https://orcid.org/0000-0001-8855-8647 |
| _version_ | 1826190048720060416 |
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| author | Lee, Tong Ihn Young, Richard A. Young, Richard A. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lee, Tong Ihn Young, Richard A. Young, Richard A. |
| author_sort | Lee, Tong Ihn |
| collection | MIT |
| description | Available in PMC 2014 March 14. |
| first_indexed | 2024-09-23T08:34:15Z |
| format | Article |
| id | mit-1721.1/103908 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:34:15Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1039082022-09-23T13:00:42Z Transcriptional Regulation and Its Misregulation in Disease Lee, Tong Ihn Young, Richard A. Young, Richard A. Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Young, Richard A. Available in PMC 2014 March 14. The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease. National Institutes of Health (U.S.) (NIH grant CA146445) National Institutes of Health (U.S.) (NIH grant HG002668) 2016-08-11T20:38:08Z 2016-08-11T20:38:08Z 2013-03 Article http://purl.org/eprint/type/JournalArticle 00928674 http://hdl.handle.net/1721.1/103908 Lee, Tong Ihn, and Richard A. Young. "Transcriptional Regulation and Its Misregulation in Disease." Cell 152:6 (March 2013), pp. 1237-1251. https://orcid.org/0000-0001-8855-8647 en_US http://dx.doi.org/10.1016/j.cell.2013.02.014 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Lee, Tong Ihn Young, Richard A. Young, Richard A. Transcriptional Regulation and Its Misregulation in Disease |
| title | Transcriptional Regulation and Its Misregulation in Disease |
| title_full | Transcriptional Regulation and Its Misregulation in Disease |
| title_fullStr | Transcriptional Regulation and Its Misregulation in Disease |
| title_full_unstemmed | Transcriptional Regulation and Its Misregulation in Disease |
| title_short | Transcriptional Regulation and Its Misregulation in Disease |
| title_sort | transcriptional regulation and its misregulation in disease |
| url | http://hdl.handle.net/1721.1/103908 https://orcid.org/0000-0001-8855-8647 |
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