Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities
Flow chemistry has attracted significant interest in pharmaceutical development, where substantial efforts have been directed toward the design of continuous processes. Here, we report a total synthesis of atropine in flow that features an unusual hydroxymethylation and separation of several byprodu...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Akadémiai Kiadó Zrt.
2016
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| Online Access: | http://hdl.handle.net/1721.1/103924 https://orcid.org/0000-0001-5511-5620 https://orcid.org/0000-0002-8601-7799 |