Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells
Curcumin, a natural chemical compound found in Curcuma longa, has been applied in multiple medicinal areas from antibiotic to antitumor treatment. However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hindering its clinical utilization....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | http://hdl.handle.net/1721.1/103954 |
| _version_ | 1826211692375179264 |
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| author | Xu, Ying-Qi Chen, Wen-Rong Tsosie, Jonathan Xie, Xi Li, Peng Wan, Jian-Bo He, Cheng-Wei Chen, Mei-He |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Xu, Ying-Qi Chen, Wen-Rong Tsosie, Jonathan Xie, Xi Li, Peng Wan, Jian-Bo He, Cheng-Wei Chen, Mei-He |
| author_sort | Xu, Ying-Qi |
| collection | MIT |
| description | Curcumin, a natural chemical compound found in Curcuma longa, has been applied in multiple medicinal areas from antibiotic to antitumor treatment. However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hindering its clinical utilization. To address these issues, we have developed a novel niosome system composed of nonionic surfactants: Span 80, Tween 80, and Poloxamer 188. Curcumin was encapsulated in the niosomes with a high entrapment efficiency of 92.3 [plus or minus] 0.4%. This system provided controlled release of curcumin, thereby improving its therapeutic capability. Dynamic dialysis was conducted to evaluate the in vitro drug release of curcumin-niosomes. Curcumin-niosomes exhibited enhanced cytotoxic activity and apoptotic rate against ovarian cancer A2780 cells compared with freely dispersed curcumin. These results demonstrate that the curcumin-niosome system is a promising strategy for the delivery of curcumin and ovarian cancer therapy. |
| first_indexed | 2024-09-23T15:10:00Z |
| format | Article |
| id | mit-1721.1/103954 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:10:00Z |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/1039542022-10-02T01:04:40Z Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells Xu, Ying-Qi Chen, Wen-Rong Tsosie, Jonathan Xie, Xi Li, Peng Wan, Jian-Bo He, Cheng-Wei Chen, Mei-He Koch Institute for Integrative Cancer Research at MIT Tsosie, Jonathan Curcumin, a natural chemical compound found in Curcuma longa, has been applied in multiple medicinal areas from antibiotic to antitumor treatment. However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hindering its clinical utilization. To address these issues, we have developed a novel niosome system composed of nonionic surfactants: Span 80, Tween 80, and Poloxamer 188. Curcumin was encapsulated in the niosomes with a high entrapment efficiency of 92.3 [plus or minus] 0.4%. This system provided controlled release of curcumin, thereby improving its therapeutic capability. Dynamic dialysis was conducted to evaluate the in vitro drug release of curcumin-niosomes. Curcumin-niosomes exhibited enhanced cytotoxic activity and apoptotic rate against ovarian cancer A2780 cells compared with freely dispersed curcumin. These results demonstrate that the curcumin-niosome system is a promising strategy for the delivery of curcumin and ovarian cancer therapy. 2016-08-17T20:44:54Z 2016-08-17T20:44:54Z 2016-07 2016-05 2016-08-03T07:47:39Z Article http://purl.org/eprint/type/JournalArticle 1687-4110 1687-4129 http://hdl.handle.net/1721.1/103954 Xu, Ying-Qi, Wen-Rong Chen, Jonathan K. Tsosie, Xi Xie, Peng Li, Jian-Bo Wan, Cheng-Wei He, and Mei-Wan Chen. “Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells.” Journal of Nanomaterials 2016 (2016): 1-9. en http://dx.doi.org/10.1155/2016/6365295 Journal of Nanomaterials Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2016 Ying-Qi Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Xu, Ying-Qi Chen, Wen-Rong Tsosie, Jonathan Xie, Xi Li, Peng Wan, Jian-Bo He, Cheng-Wei Chen, Mei-He Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells |
| title | Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells |
| title_full | Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells |
| title_fullStr | Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells |
| title_full_unstemmed | Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells |
| title_short | Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells |
| title_sort | niosome encapsulation of curcumin characterization and cytotoxic effect on ovarian cancer cells |
| url | http://hdl.handle.net/1721.1/103954 |
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