MicroRNA networks regulate development of brown adipocytes
Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. Here we sum...
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| Format: | Article |
| Language: | en_US |
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2016
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| Online Access: | http://hdl.handle.net/1721.1/103981 https://orcid.org/0000-0002-7029-7415 |
| _version_ | 1811070884886085632 |
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| author | Trajkovski, Mirko Lodish, Harvey F |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Trajkovski, Mirko Lodish, Harvey F |
| author_sort | Trajkovski, Mirko |
| collection | MIT |
| description | Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. Here we summarize recent research showing that several BAT-expressed microRNAs (miRNAs) play important roles in regulating differentiation and metabolism of brown and beige adipocytes; we discuss the key mRNA targets downregulated by these miRNAs and show how these miRNAs affect directly or indirectly transcription factors important for BAT development. We suggest that these miRNAs could be part of novel therapeutics to increase BAT in humans. |
| first_indexed | 2024-09-23T08:43:12Z |
| format | Article |
| id | mit-1721.1/103981 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:43:12Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | mit-1721.1/1039812022-09-30T10:45:32Z MicroRNA networks regulate development of brown adipocytes Trajkovski, Mirko Lodish, Harvey F Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Lodish, Harvey F. Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. Here we summarize recent research showing that several BAT-expressed microRNAs (miRNAs) play important roles in regulating differentiation and metabolism of brown and beige adipocytes; we discuss the key mRNA targets downregulated by these miRNAs and show how these miRNAs affect directly or indirectly transcription factors important for BAT development. We suggest that these miRNAs could be part of novel therapeutics to increase BAT in humans. National Institutes of Health (U.S.) (grants DK047618, DK 068348, and 5P01 HL066105) 2016-08-25T16:46:53Z 2016-08-25T16:46:53Z 2013-09 Article http://purl.org/eprint/type/JournalArticle 10432760 http://hdl.handle.net/1721.1/103981 Trajkovski, Mirko, and Harvey Lodish. “MicroRNA Networks Regulate Development of Brown Adipocytes.” Trends in Endocrinology & Metabolism 24.9 (2013): 442–450. https://orcid.org/0000-0002-7029-7415 en_US http://dx.doi.org/10.1016/j.tem.2013.05.002 Trends in Endocrinology & Metabolism Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf PMC |
| spellingShingle | Trajkovski, Mirko Lodish, Harvey F MicroRNA networks regulate development of brown adipocytes |
| title | MicroRNA networks regulate development of brown adipocytes |
| title_full | MicroRNA networks regulate development of brown adipocytes |
| title_fullStr | MicroRNA networks regulate development of brown adipocytes |
| title_full_unstemmed | MicroRNA networks regulate development of brown adipocytes |
| title_short | MicroRNA networks regulate development of brown adipocytes |
| title_sort | microrna networks regulate development of brown adipocytes |
| url | http://hdl.handle.net/1721.1/103981 https://orcid.org/0000-0002-7029-7415 |
| work_keys_str_mv | AT trajkovskimirko micrornanetworksregulatedevelopmentofbrownadipocytes AT lodishharveyf micrornanetworksregulatedevelopmentofbrownadipocytes |